Efficient Flow Synthesis of Glycidyl Ether Using BuSnCl 3 as a Mild Lewis Acid

被引：0

作者：

Kasakado, Takayoshi ^{[1
]}

Nakamura, Masahito ^{[2
]}

Nishizawa, Akihiro ^{[3
]}

Hosomi, Tetsuya ^{[3
]}

Ryu, Ilhyong ^{[1
,4
]}

Fukuyama, Takahide ^{[2
]}

机构：

[1] Osaka Metropolitan Univ, Org Res Promot, Sakai, Osaka 5998531, Japan

[2] Osaka Metropolitan Univ, Grad Sch Sci, Dept Chem, Osaka 5588585, Japan

[3] Nagase ChemteX Corp, Tatsuno, Hyogo 6794124, Japan

[4] Natl Yang Ming Chiao Tung Univ NYCU, Dept Appl Chem, Hsinchu 30010, Taiwan

来源：

SYNTHESIS-STUTTGART | 2024年 / 56卷 / 20期

基金：

日本学术振兴会;

关键词：

flow synthesis; glycidyl ethers; epichlorohydrin; BuSnCl (3); Lewis acids; chlorohydrin; CATION-BINDING; EPOXY; POLYMERIZATION; TRANSITION; CATALYSTS; EPOXIDES; ALCOHOL; EUGENOL; REACTOR; RESIN;

D O I：

10.1055/a-2359-8893

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ring-opening protocol of epichlorohydrin with 2-ethylhexanol was investigated for the synthesis of the corresponding chlorohydrin ether. BuSnCl3 proved to be an efficient mild Lewis acid catalyst, yielding the product with high selectivity. A scalable flow synthesis was achieved by modifying the flow setup. The flow synthesis of the corresponding glycidyl ether from the chlorohydrin ether was also carried out in an efficient manner by using the basic treatment.

引用

页码：3142 / 3146

页数：5

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