Anti-inflammatory benefits of semaglutide: State of the art

被引：9
作者：
Yaribeygi, Habib [1 ]
Maleki, Mina [2 ]
Jamialahmadi, Tannaz [3 ,4 ]
Sahebkar, Amirhossein [5 ,6 ]
机构：
[1] Semnan Univ Med Sci, Res Ctr Physiol, Semnan, Iran
[2] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran, Iran
[3] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Mashhad, Iran
[4] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran
[5] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran
[6] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
来源：
JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY | 2024年 / 36卷
关键词：
GLP-1; Semaglutide; Diabetes mellitus; Insulin resistance; Inflammation; INFLAMMATORY CYTOKINES; LIRAGLUTIDE; MECHANISM; MICE; HYPERGLYCEMIA; OBESITY;
D O I：
10.1016/j.jcte.2024.100340
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Individuals with diabetes often have chronic inflammation and high levels of inflammatory cytokines, leading to insulin resistance and complications. Anti-inflammatory agents are proposed to prevent these issues, including using antidiabetic medications with anti-inflammatory properties like semaglutide, a GLP-1 analogue. Semaglutide not only lowers glucose but also shows potential anti-inflammatory effects. Studies suggest it can modulate inflammatory responses and benefit those with diabetes. However, the exact mechanisms of its antiinflammatory effects are not fully understood. This review aims to discuss the latest findings on semaglutide's anti-inflammatory effects and the potential pathways involved.
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页数：6
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共 93 条
  • [1] Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc11-S062, 10.2337/dc10-S011, 10.2337/dc13-S067, 10.2337/dc14-S081, 10.2337/dc11-S011, 10.2337/dc13-S011, 10.2337/dc12-s011, 10.2337/dc10-S062, 10.2337/dc12-s064]
  • [2] A Pharmacological and Clinical Overview of Oral Semaglutide for the Treatment of Type 2 Diabetes
    Andersen, Andreas
    Knop, Filip Krag
    Vilsboll, Tina
    [J]. DRUGS, 2021, 81 (09) : 1003 - 1030
  • [3] Once-Weekly Dulaglutide for the Treatment of Youths with Type 2 Diabetes
    Arslanian, Silva A.
    Hannon, Tamara
    Zeitler, Philip
    Chao, Lily C.
    Boucher-Berry, Claudia
    Barrientos-Perez, Margarita
    Bismuth, Elise
    Dib, Sergio
    Cho, Jang Ik
    Cox, David
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (05) : 433 - 443
  • [4] Curcumin Therapeutic Modulation of the Wnt Signaling Pathway
    Ashrafizadeh, Milad
    Ahmadi, Zahra
    Mohamamdinejad, Reza
    Yaribeygi, Habib
    Serban, Maria-Corina
    Orafai, Hossein M.
    Sahebkar, Amirhossein
    [J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2020, 21 (11) : 1006 - 1015
  • [5] The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists
    Bendotti, Giulia
    Montefusco, Laura
    Lunati, Maria Elena
    Usuelli, Vera
    Pastore, Ida
    Lazzaroni, Elisa
    Assi, Emma
    Seelam, Andy Joe
    El Essawy, Basset
    Jang, Jun
    Loretelli, Cristian
    D'Addio, Francesca
    Berra, Cesare
    Ben Nasr, Moufida
    Zuccotti, GianVincenzo
    Fiorina, Paolo
    [J]. PHARMACOLOGICAL RESEARCH, 2022, 182
  • [6] Semaglutide for the treatment of overweight and obesity: A review
    Bergmann, Natasha Chidekel
    Davies, Melanie J.
    Lingvay, Ildiko
    Knop, Filip K.
    [J]. DIABETES OBESITY & METABOLISM, 2023, 25 (01) : 18 - 35
  • [7] Exenatide
    Bray, GM
    [J]. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2006, 63 (05) : 411 - 418
  • [8] Relationship between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues
    Burgos-Moron, Estefania
    Abad-Jimenez, Zaida
    Martinez de Maranon, Aranzazu
    Iannantuoni, Francesca
    Escribano-Lopez, Irene
    Lopez-Domenech, Sandra
    Salom, Christian
    Jover, Ana
    Mora, Vicente
    Roldan, Ildefonso
    Sola, Eva
    Rocha, Milagros
    Victor, Victor M.
    [J]. JOURNAL OF CLINICAL MEDICINE, 2019, 8 (09)
  • [9] Buteau J, 2011, AV DIABETOL, V27, P3
  • [10] Long-acting preparations of exenatide
    Cai, Yunpeng
    Wei, Liangming
    Ma, Liuqing
    Huang, Xiwen
    Tao, Anqi
    Liu, Zhenguo
    Yuan, Weien
    [J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2013, 7 : 963 - 970
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