Expression of E-Cadherin and Ber-EP4 in the Trophoblastic Tissues of Intrauterine and Ectopic Tubal Pregnancies

被引：0

作者：

Koc, Nermin ^{[1
]}

Arinkan, Sevcan Arzu ^{[2
]}

Sonmez, Cansu ^{[1
]}

Kaya, Berker ^{[3
]}

机构：

[1] Univ Hlth Sci, Haydarpasa Numune Training & Res Hosp, Dept Pathol, Istanbul, Turkiye

[2] Cent Hosp Kristianstad, Dept Obstet & Gynecol, Kristianstad, Sweden

[3] Istanbul Univ, Dept Internal Med, Istanbul, Turkiye

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2024年 / 43卷 / 04期

关键词：

E-cadherin; Ber-EP4; ectopic pregnancy; cytotrophoblast; trophoblasts; EPITHELIAL-MESENCHYMAL TRANSITION; PLACENTA-ACCRETA; PHENOTYPE; ETIOLOGY;

D O I：

10.1080/15513815.2024.2368579

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Introduction: We investigated the role of E-cadherin and Ber-EP4 in tubal pregnancy by comparing their expressions in epithelial and trophoblastic cells both in ectopic tubal and intrauterine pregnancies. Methods: The Formalin-fixed paraffin embedded blocks of 17 intrauterine and 17 tubal pregnancies were immunohistochemically stained with E-cadherin and Ber-EP4. Results: E-cadherin was expressed in the epithelium, villous and extravillous trophoblast in tubal and intrauterine pregnancies but not in the syncytiotrophoblast. The staining intensity was lower in the extra-villous trophoblast in tubal ectopic pregnancies compared with intrauterine pregnancies. Ber-EP4 was expressed in the epithelium of tubal and intrauterine pregnancies and only in villous cytotrophoblast. The intensity of staining in tubal pregnancy was higher than in intrauterine pregnancy. Discussion: The loss of E-cadherin expression in extra-villous trophoblast and increased expression of Ber-EP4 in the villous cytotrophoblast may play a role in the formation of tubal pregnancy by allowing the blastocyst to attach to the tubal epithelium.

引用

页码：290 / 299

页数：10

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