High serum copper as a risk factor of all-cause and cause-specific mortality among US adults, NHANES 2011-2014

被引:3
|
作者
Zeng, Xianghui [1 ]
Zhou, Lanqian [2 ]
Zeng, Qingfeng [1 ,3 ]
Zhu, Hengqing [4 ]
Luo, Jianping [5 ]
机构
[1] Ganzhou Hosp Tradit Chinese Med, Dept Cardiol, Ganzhou, Jiangxi, Peoples R China
[2] Nanchang Univ, Affiliated Hosp 2, Dept Anesthesiol, Nanchang, Jiangxi, Peoples R China
[3] Gannan Med Univ, Affiliated Hosp 2, Emergency Dept, Ganzhou, Jiangxi, Peoples R China
[4] Ganzhou Municipal Hosp, Guangdong Prov Peoples Hosp, Ganzhou Hosp, Dept Cardiol, Ganzhou, Jiangxi, Peoples R China
[5] Ganzhou Peoples Hosp, Dept Cardiol, Ganzhou, Jiangxi, Peoples R China
来源
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2024年 / 11卷
关键词
serum copper; all-cause mortality; cancer mortality; cardiovascular disease mortality; national health and nutrition examination survey; CU; ZN SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; ZINC; EXPOSURE; DISEASE; IRON; MECHANISMS; TOXICITY; DEATH;
D O I
10.3389/fcvm.2024.1340968
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Several studies have shown that serum copper levels are related to coronary heart disease, diabetes, and cancer. However, the association of serum copper levels with all-cause, cause-specific [including cardiovascular disease (CVD) and cancer] mortality remains unclear. Objectives This study aimed to prospectively examine the association of copper exposure with all-cause, CVD, and cancer mortality among US adults. Methods The data for this analysis was obtained from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2014. Mortality from all-causes, CVD, and cancer mortality was linked to US National Death Index mortality data. Cox regression models were used to estimate the association between serum copper levels and all-cause, CVD, and cancer mortality. Results A total of 2,863 adults were included in the main study. During the mean follow-up time of 81.2 months, 236 deaths were documented, including 68 deaths from cardiovascular disease and 57 deaths from cancer. The weighted mean overall serum copper levels was 117.2 ug/L. After adjusting for all of the covariates, compared with participants with low (1st tertile, <103 mu g/L)/medium (2st tertile, 103-124 mu g/L) serum copper levels, participants with high serum copper levels (3rd tertile, >= 124 mu g/L) had a 1.75-fold (95% CI, 1.05-2.92)/1.78-fold (1.19,2.69) increase in all-cause mortality, a 2.35-fold (95% CI, 1.04-5.31)/3.84-fold (2.09,7.05) increase in CVD mortality and a 0.97-fold (95% CI, 0.28-3.29)/0.86-fold (0.34,2.13) increase in cancer mortality. In addition, there was a linear dose-response association between serum copper concentration with all-cause and CVD mortality (P for nonlinear > 0.05). Conclusions This prospective study found that serum copper concentrations were linearly associated with all-cause and CVD mortality in US adults. High serum copper levels is a risk factor for all-cause and CVD mortality.
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页数:9
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