The Role of Immune Cells in Liver Regeneration

被引：1

作者：

Wen, Yankai ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Anesthesiol Crit Care & Pain Med, Houston, TX 77030 USA

来源：

LIVERS | 2023年 / 3卷 / 03期

关键词：

liver regeneration; liver repair; hepatectomy; proliferation; hepatic progenitor cells; immune cells; macrophages; NATURAL-KILLER-CELL; PARTIAL-HEPATECTOMY; T-CELLS; 90-PERCENT HEPATECTOMY; ENDOTHELIAL-CELL; DENDRITIC CELLS; KUPFFER CELLS; TISSUE-REPAIR; EARLY PHASE; NK CELLS;

D O I：

10.3390/livers3030029

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The liver is the only organ that can regenerate and regain its original tissue-to-body weight ratio within a short period of time after tissue loss. Insufficient liver regeneration in patients after partial hepatectomy or liver transplantation with partial liver grafts often leads to post-hepatectomy liver failure or small-for-size syndrome, respectively. Enhancing liver regeneration after liver injury might improve outcomes and increase patient survival. Liver regeneration comprises hepatocyte proliferation, and hepatic progenitor cell expansion and differentiation into hepatocytes. The immune system is intensively involved in liver regeneration. The current review provides a comprehensive overview of the diverse roles played by immune cells in liver regeneration. Macrophages, neutrophils, eosinophils, basophils, mast cells, platelets, dendritic cells, type 1 innate lymphoid cells, B cells, and T cells are implicated in promoting liver regeneration, while natural killer cells and overactivated natural killer T cells are supposed to inhibit hepatocyte proliferation. We also highlight the predominant underlying mechanisms mediated by immune cells, which may contribute to the development of novel strategies for promoting liver regeneration in patients with liver diseases.

引用

收藏

页码：383 / 396

页数：14

相关论文

共 126 条

[1] Loss of NF-κB activation in Kupffer cell-depleted mice impairs liver regeneration after partial hepatectomy [J].

Abshagen, Kerstin ;

Eipel, Christian ;

Kalff, Joerg C. ;

Menger, Michael D. ;

Vollmar, Brigitte .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2007, 292 (06) :G1570-G1577

[2] Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners [J].

Ahmed, Yeni Ait ;

Fu, Yaojie ;

Rodrigues, Robim M. ;

He, Yong ;

Guan, Yukun ;

Guillot, Adrien ;

Ren, Ruixue ;

Feng, Dechun ;

Hidalgo, Juan ;

Ju, Cynthia ;

Lafdil, Fouad ;

Gao, Bin .

CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 18 (09) :2165-2176

[3] Immediate Postoperative Low Platelet Count is Associated With Delayed Liver Function Recovery After Partial Liver Resection [J].

Alkozai, Edris M. ;

Nijsten, Maarten W. ;

de Jong, Koert P. ;

de Boer, Marieke T. ;

Peeters, Paul M. J. G. ;

Slooff, Maarten J. ;

Porte, Robert J. ;

Lisman, Ton .

ANNALS OF SURGERY, 2010, 251 (02) :300-306

[4] Contribution of the lymphotoxin β receptor to liver regeneration [J].

Anders, RA ;

Subudhi, SK ;

Wang, J ;

Pfeffer, K ;

Fu, YX .

JOURNAL OF IMMUNOLOGY, 2005, 175 (02) :1295-1300

[5] Platelet Transforming Growth Factor-β1 Induces Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6 [J].

Balaphas, Alexandre ;

Meyer, Jeremy ;

Perozzo, Remo ;

Zeisser-Labouebe, Magali ;

Berndt, Sarah ;

Turzi, Antoine ;

Fontana, Pierre ;

Scapozza, Leonardo ;

Gonelle-Gispert, Carmen ;

Buehler, Leo H. .

CELLS, 2020, 9 (05)

[6] B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration [J].

Behnke, Kristina ;

Zhuang, Yuan ;

Xu, Haifeng C. ;

Sundaram, Balamurugan ;

Reich, Maria ;

Shinde, Prashant V. ;

Huang, Jun ;

Modares, Nastaran Fazel ;

Tumanov, Alexei V. ;

Polz, Robin ;

Scheller, Juergen ;

Ware, Carl F. ;

Pfeffer, Klaus ;

Keitel, Verena ;

Haessinger, Dieter ;

Pandyra, Aleksandra A. ;

Lang, Karl S. ;

Lang, Philipp A. .

HEPATOLOGY, 2018, 68 (06) :2348-2361

[7] TIGIT Safeguards Liver Regeneration Through Regulating Natural Killer Cell-Hepatocyte Crosstalk [J].

Bi, Jiacheng ;

Zheng, Xiaodong ;

Chen, Yongyan ;

Wei, Haiming ;

Sun, Rui ;

Tian, Zhigang .

HEPATOLOGY, 2014, 60 (04) :1389-1398

[8] Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection [J].

Bleriot, Camille ;

Dupuis, Theo ;

Jouvion, Gregory ;

Eberl, Gerard ;

Disson, Olivier ;

Lecuit, Marc .

IMMUNITY, 2015, 42 (01) :145-158

[9] Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease [J].

Boulter, Luke ;

Govaere, Olivier ;

Bird, Tom G. ;

Radulescu, Sorina ;

Ramachandran, Prakash ;

Pellicoro, Antonella ;

Ridgway, Rachel A. ;

Seo, Sang Soo ;

Spee, Bart ;

Van Rooijen, Nico ;

Sansom, Owen J. ;

Iredale, John P. ;

Lowell, Sally ;

Roskams, Tania ;

Forbes, Stuart J. .

NATURE MEDICINE, 2012, 18 (04) :572-579

[10] Augmentation of the early phase of liver regeneration after 70% partial hepatectomy in rats following selective Kupffer cell depletion [J].

Boulton, RA ;

Alison, MR ;

Golding, M ;

Selden, C ;

Hodgson, HJF .

JOURNAL OF HEPATOLOGY, 1998, 29 (02) :271-280

← 1 2 3 4 5 6 7 8 9 10 →