Geographic Variation of Antidementia and Antipsychotic Medication Use Among US Nursing Home Residents With Dementia

被引:2
作者
Rataj, Alison [1 ]
Alcusky, Matthew [1 ]
Baek, Jonggyu [2 ]
Ott, Brian [3 ]
Lapane, Kate L. [1 ]
机构
[1] Univ Massachusetts, Chan Med Sch, Dept Populat & Quantitat Hlth Sci, Div Epidemiol, 55 Lake Ave, Worcester, 01605, England
[2] Univ Massachusetts, Chan Med Sch, Dept Populat & Quantitat Hlth Sci, Div Epidemiol, Worcester, MA, Brazil
[3] Brown Univ, Alpert Med Sch, Dept Neurol, Providence, RI USA
关键词
antipsychotics; memantine; cholinesterase inhibitors; nursing homes; geographic variation; CHOLINESTERASE-INHIBITORS; ALZHEIMER-DISEASE; CARE; QUALITY; MEMANTINE; IMPACT; DRUGS;
D O I
10.1097/MLR.0000000000002016
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background:Several antidementia medications have been approved for symptomatic treatment of cognitive and functional impairment due to Alzheimer disease. Antipsychotics are often prescribed off-label for behavioral symptoms.Objective:The aim of this study was to describe the basis for regional variation in antidementia and antipsychotic medication use.Setting:US nursing homes (n=9735), hospital referral regions (HRR; n=289).Subjects:Long-stay residents with dementia (n=273,004).Methods:Using 2018 Minimum Data Set 3.0 linked to Medicare data, facility information, and Dartmouth Atlas files, we calculated prevalence of use and separate multilevel logistic models [outcomes: memantine, cholinesterase inhibitor (ChEI), antipsychotic use] estimated adjusted odds ratios (aOR) and 95% CIs for resident, facility, and HRR characteristics. We then fit a series of cross-classified multilevel logistic models to estimate the proportional change in cluster variance (PCV).Results:Overall, 20.9% used antipsychotics, 16.1% used memantine, and 23.3% used ChEIs. For antipsychotics, facility factors [eg, use of physical restraints (aOR: 1.08; 95% CI: 1.05-1.11) or poor staffing ratings (aOR: 1.10; 95% CI: 1.06-1.14)] were associated with more antipsychotic use. Nursing homes in HRRs with the highest health care utilization had greater antidementia drug use (aOR memantine: 1.68; 95% CI: 1.44-1.96). Resident/facility factors accounted for much regional variation in antipsychotics (PCVSTATE: 27.80%; PCVHRR: 39.54%). For antidementia medications, HRR-level factors accounted for most regional variation (memantine PCVSTATE: 37.44%; ChEI PCVSTATE: 39.02%).Conclusion:Regional variations exist in antipsychotic and antidementia medication use among nursing home residents with dementia suggesting the need for evidence-based protocols to guide the use of these medications.
引用
收藏
页码:511 / 520
页数:10
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