Photoredox-Catalyzed Sequential Decarboxylative/Defluorinative Aminoalkylation of CF3-Alkenes with N-Arylglycines

被引：6

作者：

Xin, Hong ^{[1
]}

Zhang, Lu ^{[1
]}

Liao, Jinyi ^{[1
]}

Duan, Xin-Hua ^{[1
,2
]}

Yang, Xu ^{[3
]}

Guo, Li-Na ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Minist Educ, Sch Chem, Dept Chem,Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Xi An Jiao Tong Univ, Sch Elect Engn, Xian 710049, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 28期

基金：

中国国家自然科学基金;

关键词：

GEM-DIFLUOROALKENES; BOND ACTIVATION; MONOFLUOROALKENES; DERIVATIVES; ACIDS;

D O I：

10.1021/acs.orglett.4c02154

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A photoredox-catalyzed sequential decarboxylative/defluorinative aminoalkylation of CF3-alkenes with N-arylglycines is described. This metal-free and redox-neutral protocol provided efficient access to the monofluoroalkenyl-1,5-diamines in good yields with excellent functional group compatibility. Mechanistic studies revealed that the reaction proceeds via a radical pathway with the gem-difluoroalkenyl amine as an intermediate.

引用

页码：6030 / 6034

页数：5

共 9 条

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