Tumor-treating fields in cancer therapy: advances of cellular and molecular mechanisms

被引：3

作者：

Xiao, Tong ^{[1
]}

Zheng, Hao ^{[1
]}

Zu, Kaiyang ^{[1
]}

Yue, Youjia ^{[2
]}

Wang, Ying ^{[1
]}

机构：

[1] Capital Med Univ, Sch Basic Med Sci, Beijing 100069, Peoples R China

[2] Capital Med Univ, Sch Biomed Engineeringg, Beijing 100069, Peoples R China

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2025年 / 27卷 / 01期

基金：

国家重点研发计划;

关键词：

Tumor-treating fields; Alternating electric fields; Cancer; Therapy; Mechanism; ALTERNATING ELECTRIC-FIELDS; CELLS IN-VITRO; GLIOBLASTOMA; COMBINATION; TTFIELDS; EFFICACY; PROLIFERATION; CHEMOTHERAPY; DISRUPTION; EXPRESSION;

D O I：

10.1007/s12094-024-03551-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-Treating Fields (TTFields) use intermediate-frequency and low-intensity electric fields to inhibit tumor cells. However, their mechanisms are still not well understood. This article reviews their key antitumor mechanisms at the cellular and molecular levels, including inhibition of proliferation, induction of death, disturbance of migration, and activation of the immune system. The multifaceted biological effects in combination with other cancer treatments are also summarized. The deep insight into their mechanism will help develop more potential antitumor treatments.

引用

页码：1 / 14

页数：14