Exploring Acute Pancreatitis in Kidney Transplant Recipients: A Multicentre Retrospective Cohort Analysis of Incidence, Causes, and Clinical Outcomes

被引:0
作者
Basic-Jukic, Nikolina [1 ,2 ]
Androvic, Alen [3 ]
Beck, David [2 ]
Radunovic, Danilo [4 ]
Juric, Ivana [1 ]
Furic-Cunko, Vesna [1 ]
Katalinic, Lea [1 ]
Sabljic, Zoran [1 ]
Fistrek-Prlic, Margareta [1 ]
Atic, Armin [1 ]
Kljajic, Marina [1 ]
Jelakovic, Bojan [1 ,2 ]
机构
[1] Univ Hosp Ctr Zagreb, Dept Nephrol Arterial Hypertens Dialysis & Transpl, Zagreb 10000, Croatia
[2] Univ Zagreb, Sch Med, Zagreb 10000, Croatia
[3] Gen Hosp Varazdin, Dept Nephrol, Varazhdin 42000, Croatia
[4] Clin Ctr Montenegro, Dept Nephrol, Podgorica 81000, Montenegro
关键词
acute pancreatitis; kidney transplantation; sirolimus; tacrolimus; cannabis; RECURRENT ACUTE-PANCREATITIS; QUALITY-OF-LIFE; GASTROINTESTINAL COMPLICATIONS; FLUID RESUSCITATION; PERITONEAL-DIALYSIS; LACTATED RINGERS; GLOBAL INCIDENCE; NORMAL SALINE; MORTALITY; HYPERCALCEMIA;
D O I
10.3390/jcm13123366
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The aim of this multicentre retrospective study is to determine the incidence, etiology, clinical characteristics, and outcomes of kidney transplant recipients diagnosed and treated for acute pancreatitis. Methods: We analyzed data from kidney transplant recipients who received kidney allografts between October 1973 and December 2023 and were diagnosed and treated for acute pancreatitis. Results: Of 2482 patients who received kidney allografts, 10 (0.4%) (5 male) were diagnosed with acute pancreatitis, with a mean age of 48.6 years. Patients were diagnosed with acute pancreatitis between 3 weeks and 24 years after the transplantation. Possible etiologies included cholecystolithiasis, COVID-19, hypercalcemia, postprocedural, use of cannabis, trimetoprim-sulphometoxasole, statins, sirolimus, tacrolimus and obesity. There was no suspected etiology in two patients. Patients were treated with aggressive hydration, pain alleviation and antibiotics if indicated. Four patients developed complications. Local complications included peripancreatic collections, pseudocyst, and abscesses formation, while systemic complications occurred in the form of Cytomegalovirus (CMV) reactivation and urinary tract infection. All patients survived with preserved kidney allograft function. Conclusions: Acute pancreatitis in kidney transplant recipients is rare. However, it may be linked to significant morbidity and mortality. While symptoms may be nonspecific and brought on by a variety of viral and non-infectious illnesses, as well as adverse effects from immunosuppressive medications, a high degree of awareness is required.
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页数:12
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