Malic Acid as a Green Catalyst for the N-Boc Protection under Solvent-free Condition

被引：6
|
作者：
Pise, Ashok [1 ]
Patil, Shripad M. [1 ]
Ingale, Ajit P. [1 ]
机构：
[1] Savitribai Phule Pune Univ, Dada Patil Mahavidyalaya, Karjat, India
来源：
LETTERS IN ORGANIC CHEMISTRY | 2024年 / 21卷 / 07期
关键词：
Amine; Di-ter-butyl dicarbonate; malic acid; solvent-free condition; bioactive compounds; synthesis; HIGHLY EFFICIENT CATALYST; TERT-BUTYL DICARBONATE; IONIC LIQUID CATALYST; ARYL AMINES; ONE-POT; BUTOXYCARBONYLATION; PROTOCOL; MILD; BUTYLOXYCARBONYLATION; ORGANOCATALYST;
D O I：
10.2174/0115701786278928231218113855
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A protocol for the Chemoselective N-Boc protection of various types of amines has been developed. This includes heteroaryl, aliphatic, and alicyclic amines. The process makes use of malic acid as a catalyst and operates efficiently at ambient temperature without the need for solvents. This technique has been proven to effectively protect a wide range of functionalized amines containing both electron-donating and electron-withdrawing substituents. The benefits of this method include its fast reaction rate, high selectivity, excellent yield, catalyst recyclability, and environmentally friendly conditions.
引用
收藏
页码：620 / 629
页数：10
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