Malic Acid as a Green Catalyst for the N-Boc Protection under Solvent-free Condition

被引：6

作者：

Pise, Ashok ^{[1
]}

Patil, Shripad M. ^{[1
]}

Ingale, Ajit P. ^{[1
]}

机构：

[1] Savitribai Phule Pune Univ, Dada Patil Mahavidyalaya, Karjat, India

来源：

LETTERS IN ORGANIC CHEMISTRY | 2024年 / 21卷 / 07期

关键词：

Amine; Di-ter-butyl dicarbonate; malic acid; solvent-free condition; bioactive compounds; synthesis; HIGHLY EFFICIENT CATALYST; TERT-BUTYL DICARBONATE; IONIC LIQUID CATALYST; ARYL AMINES; ONE-POT; BUTOXYCARBONYLATION; PROTOCOL; MILD; BUTYLOXYCARBONYLATION; ORGANOCATALYST;

D O I：

10.2174/0115701786278928231218113855

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protocol for the Chemoselective N-Boc protection of various types of amines has been developed. This includes heteroaryl, aliphatic, and alicyclic amines. The process makes use of malic acid as a catalyst and operates efficiently at ambient temperature without the need for solvents. This technique has been proven to effectively protect a wide range of functionalized amines containing both electron-donating and electron-withdrawing substituents. The benefits of this method include its fast reaction rate, high selectivity, excellent yield, catalyst recyclability, and environmentally friendly conditions.

引用

页码：620 / 629

页数：10

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