Exposure-response analyses for optimal therapeutic dose selection of ABBV-383 in patients with relapsed/refractory multiple myeloma (RRMM)

被引:0
|
作者
Polepally, Akshanth
Badillo, Jesus D.
de Almeida, Carla Biesdorf
Voorhees, Peter M.
D'Souza, Anita
Kumar, Shaji
Bueno, Orlando Felix
Rosenberg, Tanya
Pothacamury, Rajvineeth Kumar
Talati, Chetasi
Menon, Rajeev
Mensing, Sven
Engelhardt, Benjamin
机构
[1] AbbVie Inc, Ludwigshafen, Germany
[2] Wake Forest Univ, Levine Canc Inst, Plasma Cell Disorders Sect,Atrium Hlth, Dept Hematol Oncol & Blood Disorders,Sch Med, Charlotte, NC USA
[3] Froedtert & Med Coll Wisconsin Canc Ctr, Div Hematol Oncol, Dept Med, Milwaukee, WI USA
[4] Mayo Clin, Div Hematol, Rochester, MN USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
7541
引用
收藏
页数:1
相关论文
共 50 条
  • [31] A Phase 1 First-in-Human Study of Abbv-383, a BCMA x CD3 Bispecific T-Cell-Redirecting Antibody, As Monotherapy in Patients with Relapsed/Refractory Multiple Myeloma
    Voorhees, Peter M.
    D'Souza, Anita
    Weisel, Katja
    Hurd, David Duane
    Teipel, Raphael
    Chung, Alfred
    Rodriguez, Cesar
    Tuchman, Sascha A.
    Korde, Neha
    Safah, Hana
    Bueno, Orlando F.
    Pumford, Neil
    Rosenberg, Tanya S.
    Pothacamury, Rajvineeth Kumar
    Ross, Jeremy A.
    Polepally, Akshanth R.
    Lee, Shane
    Jin, Ziyi
    Talati, Chetasi
    Vij, Ravi
    Kumar, Shaji K.
    BLOOD, 2022, 140 : 4401 - 4404
  • [32] Predictive Biomarkers of Response to Venetoclax in Combination with Cobimetinib in Relapsed/Refractory Multiple Myeloma (RRMM)
    Raval, Aparna
    Hamidi, Habib
    Hwang, Olivia
    Green, Cherie
    Maia, Catarina
    Lasa, Marta
    Onishi, Maika
    Rodriguez-Otero, Paula
    San-Miguel, Jesus F.
    Gallo, Jorge D.
    Paiva, Bruno
    Schjesvold, Fredrik
    BLOOD, 2020, 136
  • [33] Exposure-Response of Quizartinib Efficacy in Patients with Relapsed/Refractory AML
    Kang, Dongwoo
    Passarell, Julie
    Abutarif, Malaz A.
    Mendell, Jeanne
    Yin, Ophelia
    BLOOD, 2019, 134
  • [34] Updated results of a phase 1, first-in-human study of ABBV-383, a BCMA x CD3 bispecific T-cell redirecting antibody, in patients with relapsed/refractory multiple myeloma
    Voorhees, Peter
    Shah, Nina
    D'Souza, Anita
    Rodriguez, Cesar
    Weisel, Katja
    Teipel, Raphael
    Hurd, David
    Bueno, Orlando
    Pumford, Neil
    Rosenberg, Tanya
    Pothacamury, Rajvineeth Kumar
    Ross, Jeremy
    Polepally, Akshanth
    Lee, Shane
    Jin, Ziyi
    Talati, Chetasi
    Kumar, Shaji
    Vij, Ravi
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 : S34 - S34
  • [35] EXPOSURE-SAFETY-EFFICACY ANALYSIS OF IXAZOMIB IN RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): DOSE SELECTION FOR PHASE III TRIAL OF IXAZOMIB MAINTENANCE THERAPY
    Gupta, N.
    Labotka, R.
    Liu, G.
    Venkatakrishnan, K.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2017, 101 (S1) : S13 - S14
  • [36] Exposure-response analysis of venetoclax in combination with carfilzomib and dexamethasone in t(11;14)-positive relapsed/refractory multiple myeloma patients
    Badawi, Mohamed
    Engelhardt, Benjamin
    Dobkowska, Edyta
    Deng, Rong
    Kaufman, Jonathan
    Menon, Rajeev
    Salem, Ahmed Hamed
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S161 - S162
  • [37] Pomalidomide (POM) with Low-Dose Dexamethasone (LoDEX) in Patients with Relapsed and Refractory Multiple Myeloma (RRMM): Outcomes Based on Prior Treatment Exposure
    Vij, Ravi
    Hofmeister, Craig C.
    Richardson, Paul G.
    Jagannath, Sundar
    Siegel, David S.
    Baz, Rachid
    Chen, Min
    Zaki, Mohamed
    Larkins, Gail
    Anderson, Kenneth C.
    BLOOD, 2012, 120 (21)
  • [38] Exposure-Response Analysis Supports a Lower Dose of Venetoclax in t(11;14)-Positive Relapsed/Refractory Multiple Myeloma Patients When Combined with Daratumumab and Dexamethasone
    Badawi, Mohamed A.
    Engelhardt, Benjamin
    Badillo, Jesus
    Suleiman, Ahmed Abbas
    Fleming, Leanne Lash
    Luo, Yan
    Kaufman, Jonathan L.
    Bahlis, Nizar Jacques
    Menon, Rajeev
    Salem, Ahmed Hamed
    BLOOD, 2022, 140 : 10122 - 10123
  • [39] Pharmacokinetics and Exposure-Response Analyses of Daratumumab in Combination Therapy Regimens for Patients with Multiple Myeloma
    Xu, Xu Steven
    Dimopoulos, Meletios A.
    Sonneveld, Pieter
    Ho, P. Joy
    Belch, Andrew
    Leiba, Merav
    Capra, Marcelo
    Gomez, David
    Medvedova, Eva
    Iida, Shinsuke
    Min, Chang-Ki
    Schecter, Jordan
    Jansson, Richard
    Zhang, Liping
    Sun, Yu-Nien
    Clemens, Pamela L.
    ADVANCES IN THERAPY, 2018, 35 (11) : 1859 - 1872