Thiazolidinone-linked-1,2,3-triazoles with (R)-Carvone as new potential anticancer agents

被引：5

作者：

Oubella, Ali ^{[1
]}

Alossaimi, Manal A. ^{[2
]}

Riadi, Yassine ^{[2
]}

Bhat, Mashooq Ahmad ^{[3
]}

Bakheit, Ahmed Hassan ^{[3
]}

Taha, Mohamed Labd ^{[1
]}

Auhmani, Aziz ^{[4
]}

Morjani, Hamid ^{[5
]}

Geesi, Mohammed H. ^{[6
]}

Itto, Moulay Youssef Ait ^{[4
]}

机构：

[1] Iboun Zohr Univ, Fac Sci, Lab Organ & Phys Chem, Appl Bioorgan Chem Team, Agadir, Morocco

[2] Prince Sattam bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, Al Kharj 11942, Saudi Arabia

[3] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

[4] Univ Cadi Ayyad, Fac Sci Semlalia, Dept Chem, Lab Organ Synth & Physico Mol Chem, BP POB 2390, Marrakech 40001, Morocco

[5] Univ Reims, Biospect Translat, BioSpecT EA7506, UFR Pharm, 51 Rue Cognacq Jay, F-51096 Reims, France

[6] Prince Sattam Bin Abdulaziz Univ, Coll Sci & Humanities Al Kharj, Dept Chem, Al Kharj, Saudi Arabia

来源：

FUTURE MEDICINAL CHEMISTRY | 2024年 / 16卷 / 14期

关键词：

(R)-Carvone; apoptosis; cancer; cytotoxic activity; molecular docking; thiazolidinone; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; DERIVATIVES; APOPTOSIS; LIMONENE; ANTIOXIDANT; INHIBITORS;

D O I：

10.1080/17568919.2024.2351287

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aim: This study explores the cytotoxic and apoptotic effects of novel thiazolidinone-1,2,3-triazole hybrids on HT-1080, A-549, and MDA-MB-231 cancer cell lines. Methods & results: The synthesized compounds underwent comprehensive characterization (NMR and HRMS) to confirm their structures and purity. Subsequent anticancer activity screening across diverse cancer cell lines revealed promising antitumor potential notably, compounds 6f and 6g. Mechanistic investigations unveiled that compound 6f triggers apoptosis through the caspase-3/7 pathway. In terms of in silico studies, the compound 6f was identified as a potent inhibitor of caspase-3 and caspase-7. Conclusion: The present study underscores the therapeutic potential of thiazolidinone-1,2,3-triazole hybrids against certain cancer cells. These findings highlight a promising avenue for the development of cancer treatment strategies utilizing these (R)-Carvone-based derivatives. [GRAPHICS] .

引用

页码：1449 / 1464

页数：16

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