Identification of Two Novel HIV-1 Unique Recombinant Forms (CRF01_AE/CRF07_BC) and Genomic Characterization in Tongzhou District of Beijing, China

被引：0

作者：

Gao, Xiang ^{[1
]}

Wang, Changdong ^{[2
,3
]}

Li, Le ^{[1
]}

Feng, Yuxin ^{[2
,4
]}

Gao, Jie ^{[1
]}

Zhou, Jinglin ^{[1
]}

Tong, Aiping ^{[5
,6
]}

Li, Zhen ^{[1
]}

Wang, Jianguo ^{[1
]}

Li, Xiaohui ^{[1
]}

Li, Hanping ^{[2
]}

Li, Lin ^{[2
]}

机构：

[1] Tongzhou Dist Ctr Dis Control & Prevent, Beijing, Peoples R China

[2] Acad Mil Med Sci, Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Dongdajie20, Beijing 100071, Peoples R China

[3] Gannan Med Univ, Sch Publ Hlth, Ganzhou, Peoples R China

[4] North China Univ Sci & Technol, Sch Publ Hlth, Tangshan, Peoples R China

[5] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China

[6] Sichuan Univ, Canc Ctr, Chengdu, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2024年 / 40卷 / 12期

基金：

中国国家自然科学基金;

关键词：

HIV-1; recombinant; genetic diversity; subtype; phylogenetic analysis; PREVALENCE;

D O I：

10.1089/aid.2024.0044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Continuous recombination and variation during replication could lead to rapid evolution and genetic diversity of HIV-1. Some studies had identified that it was easy to develop new recombinant strains of HIV-1 among the populations of men who have sex with men (MSM). Surveillance of genetic variants of HIV-1 in key populations was crucial for comprehending the development of regional HIV-1 epidemics. The finding was reported the identification of two new unique recombinant forms (URF 20110561 and 21110743) from individuals infected with HIV-1 in Tongzhou, Beijing in 2020-2022. Sequences of near full-length genome (NFLG) were amplified, then identification of amplification products used phylogenetic analyses. The result showed that CRF01_AE was the main backbone of 20110561 and 21110743. In the gag region of the virus, 20110561 was inserted two fragments from CRF07_BC, while in the pol and tat regions of the virus, 21110743 was inserted four fragments from CRF07_BC. The CRF01_AE parental origin in the genomes of the two URFs was derived from the CRF01_AE Cluster 4. In the phylogenetic tree, the CRF07_BC parental origin of 20110561 clustered with 07BC_N and the CRF07_BC parental origin of 21110743 clustered with 07BC_O. In summary, the prevalence of novel second-generation URFs of HIV-1 was monitored in Tongzhou, Beijing. The emergence of the novel CRF01_AE/CRF07_BC recombination demonstrated that there was a great significance of continuous monitoring of new URFs in MSM populations to prevent and control the spreading of new HIV-1 URFs.

引用

页码：722 / 727

页数：6