Autophagy in hematopoietic stem cell development of the embryo

被引：0

作者：

Liu, Yumin ^{[1
]}

Luo, Sifan ^{[1
]}

Chen, Yuehang ^{[1
]}

Li, Zhuan ^{[1
]}

机构：

[1] Southern Med Univ, Sch Basic Med Sci, Dept Dev Biol, Key Lab Funct Prote Guangdong Prov, 7th Floor,Life Sci Bldg, Guangzhou 510515, Peoples R China

来源：

AUTOPHAGY | 2024年 / 20卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Atg5; autophagy; hematopoietic development; hematopoietic precursors; hematopoietic stem cells; NCL;

D O I：

10.1080/15548627.2024.2355072

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hematopoietic stem cells (HSC) emerge from hemogenic endothelial cells (HEC) in the aorta-gonad-mesonephros (AGM) region of embryos, which go through the pre-HSC process. Various intrinsic and extrinsic factors are involved in this process. We recently discovered that the existence of distinct macroautophagic/autophagic statuses in hematopoietic precursors is related to the hematopoietic potential of pre-HSCs and the depletion of the Atg5 (autophagy related 5) gene specifically in endothelial cells impaired in the transition of endothelial to pre-HSCs, by hampering the autophagic process, likely via the NCL (nucleolin) pathway.Abbreviation: Atg5: autophagy related 5; EGFP: enhanced green fluorescent protein; EHT: endothelial-to-hematopoietic transition; HEC: hemogenic endothelial cell; HSC: hematopoietic stem cell; NCL: nucleolin; RFP: red fluorescent protein.

引用

页码：2112 / 2113

页数：2