Ubiquitin-dependent regulation of MYC: A promising therapeutic target

被引:0
作者
Kennedy, Bryony G. [1 ]
Morgan, Jonathan J. [1 ]
Crawford, Lisa J. [1 ]
机构
[1] Queens Univ Belfast, Patrick G Johnston Ctr Canc Res, 97 Lisburn Rd, Belfast BT9 7AE, North Ireland
来源
CLINICAL AND TRANSLATIONAL DISCOVERY | 2023年 / 3卷 / 02期
关键词
E3; ligase; MYC; TRIP12; ubiqutin; C-MYC; DEGRADATION; INHIBITION;
D O I
10.1002/ctd2.190
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页数:3
相关论文
共 10 条
[1]   E3 Ubiquitin Ligase TRIP12: Regulation, Structure, and Physiopathological Functions [J].
Brunet, Manon ;
Vargas, Claire ;
Larrieu, Dorian ;
Torrisani, Jerome ;
Dufresne, Marlene .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (22) :1-34
[2]   The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma [J].
Crawford, Lisa J. ;
Campbell, David C. ;
Morgan, Jonathan J. ;
Lawson, Michelle A. ;
Down, Jennifer M. ;
Chauhan, Dharminder ;
McAvera, Roisin M. ;
Morris, Treen C. ;
Hamilton, Claudia ;
Krishnan, Aswini ;
Rajalingam, Krishnaraj ;
Chantry, Andrew D. ;
Irvine, Alexandra E. .
ONCOGENE, 2020, 39 (27) :5001-5014
[3]   Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis [J].
Huang, Hui-Lin ;
Weng, Heng-You ;
Wang, Lu-Qin ;
Yu, Chun-Hong ;
Huang, Qiao-Juan ;
Zhao, Pan-Pan ;
Wen, Jun-Zhi ;
Zhou, Hui ;
Qu, Liang-Hu .
MOLECULAR CANCER THERAPEUTICS, 2012, 11 (05) :1155-1165
[4]   TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains [J].
Kaiho-Soma, Ai ;
Akizuki, Yoshino ;
Igarashi, Katsuhide ;
Endo, Akinori ;
Shoda, Takuji ;
Kawase, Yasuko ;
Demizu, Yosuke ;
Naito, Mikihiko ;
Saeki, Yasushi ;
Tanaka, Keiji ;
Ohtake, Fumiaki .
MOLECULAR CELL, 2021, 81 (07) :1411-+
[5]   MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis [J].
Kalkat, Manpreet ;
Resetca, Diana ;
Lourenco, Corey ;
Chan, Pak-Kei ;
Wei, Yong ;
Shiah, Yu-Jia ;
Vitkin, Natasha ;
Tong, Yufeng ;
Sunnerhagen, Maria ;
Done, Susan J. ;
Boutros, Paul C. ;
Raught, Brian ;
Penn, Linda Z. .
MOLECULAR CELL, 2018, 72 (05) :836-+
[6]   PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc [J].
Li, Zhiheng ;
Lim, Su Lin ;
Tao, Yanfang ;
Li, Xiaolu ;
Xie, Yi ;
Yang, Chun ;
Zhang, Zimu ;
Jiang, You ;
Zhang, Xianbing ;
Cao, Xu ;
Wang, Hairong ;
Qian, Guanghui ;
Wu, Yi ;
Li, Mei ;
Fang, Fang ;
Liu, Ying ;
Fu, Mingcui ;
Ding, Xin ;
Zhu, Zhenghong ;
Lv, Haitao ;
Lu, Jun ;
Xiao, Sheng ;
Hu, Shaoyan ;
Pan, Jian .
FRONTIERS IN ONCOLOGY, 2020, 10
[7]   BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes [J].
Ma, Li ;
Wang, Jianwei ;
Zhang, Yongping ;
Fang, Fang ;
Ling, Jing ;
Chu, Xinran ;
Zhang, Zimu ;
Tao, Yanfang ;
Li, Xiaolu ;
Tian, Yuanyuan ;
Li, Zhiheng ;
Sang, Xu ;
Zhang, Kunlong ;
Lu, Lihui ;
Wan, Xiaomei ;
Chen, Yanling ;
Yu, Juanjuan ;
Zhuo, Ran ;
Wu, Shuiyan ;
Lu, Jun ;
Pan, Jian ;
Hu, Shaoyan .
CANCER BIOLOGY & THERAPY, 2022, 23 (01) :1-15
[8]   H Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase [J].
Peter, Stefanie ;
Bultinck, Jennyfer ;
Myant, Kevin ;
Jaenicke, Laura A. ;
Walz, Susanne ;
Muller, Judith ;
Gmachl, Michael ;
Treu, Matthias ;
Boehmelt, Guido ;
Ade, Carsten P. ;
Schmitz, Werner ;
Wiegering, Armin ;
Otto, Christoph ;
Popov, Nikita ;
Sansom, Owen ;
Kraut, Norbert ;
Eilers, Martin .
EMBO MOLECULAR MEDICINE, 2014, 6 (12) :1525-1541
[9]   MYC multimers shield stalled replication forks from RNA polymerase [J].
Solvie, Daniel ;
Baluapuri, Apoorva ;
Uhl, Leonie ;
Fleischhauer, Daniel ;
Endres, Theresa ;
Papadopoulos, Dimitrios ;
Aziba, Amel ;
Gaballa, Abdallah ;
Mikicic, Ivan ;
Isaakova, Ekaterina ;
Giansanti, Celeste ;
Jansen, Jennifer ;
Jungblut, Marvin ;
Klein, Teresa ;
Schuelein-Voelk, Christina ;
Maric, Hans ;
Doose, Soeren ;
Sauer, Markus ;
Beli, Petra ;
Rosenwald, Andreas ;
Dobbelstein, Matthias ;
Wolf, Elmar ;
Eilers, Martin .
NATURE, 2022, 612 (7938) :148-+
[10]   The long journey to bring a Myc inhibitor to the clinic [J].
Whitfield, Jonathan R. ;
Soucek, Laura .
JOURNAL OF CELL BIOLOGY, 2021, 220 (08)