Pediatric Cardio-Oncology: Screening, Risk Stratification, and Prevention of Cardiotoxicity Associated with Anthracyclines

被引：0

作者：

Liu, Xiaomeng ^{[1
]}

Ge, Shuping ^{[2
]}

Zhang, Aijun ^{[1
]}

机构：

[1] Shandong Univ, Dept Pediat, Qilu Hosp, Jinan 250012, Peoples R China

[2] Geisinger Med Clin, Dept Pediat & Adult Congenital Cardiol, Danville, PA 17822 USA

来源：

CHILDREN-BASEL | 2024年 / 11卷 / 07期

关键词：

pediatric; cardiotoxicity; anthracycline; risk stratification; monitoring; prevention; childhood cancer survivors; cardio-oncology; CHILDHOOD-CANCER SURVIVORS; ACUTE LYMPHOBLASTIC-LEUKEMIA; LONG-TERM SURVIVORS; ADULT SURVIVORS; TROPONIN-T; MYELOID-LEUKEMIA; HEART-FAILURE; DOXORUBICIN; DYSFUNCTION; DEXRAZOXANE;

D O I：

10.3390/children11070884

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Anthracyclines have significantly improved the survival of children with malignant tumors, but the associated cardiotoxicity, an effect now under the purview of pediatric cardio-oncology, due to its cumulative and irreversible effects on the heart, limits their clinical application. A systematic screening and risk stratification approach provides the opportunity for early identification and intervention to mitigate, reverse, or prevent myocardial injury, remodeling, and dysfunction associated with anthracyclines. This review summarizes the risk factors, surveillance indexes, and preventive strategies of anthracycline-related cardiotoxicity to improve the safety and efficacy of anthracyclines.

引用

页数：16

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