Polymeric scaffold integrated with nanovesicle-entrapped curcuminoids for enhanced therapeutic efficacy

被引：19

作者：

Singh, Sudarshan ^{[1
,2
,3
,4
]}

Supaweera, Nassareen ^{[1
]}

Nwabor, Ozioma F. ^{[5
]}

Yusakul, Gorawit ^{[6
]}

Chaichompoo, Waraluck ^{[7
]}

Suksamrarn, Apichart ^{[8
,9
]}

Panpipat, Worawan ^{[2
,10
]}

Chunglok, Warangkana ^{[1
,2
]}

机构：

[1] Walailak Univ, Sch Allied Hlth Sci, Nakhon Si Thammarat 80160, Thailand

[2] Walailak Univ, Food Technol & Innovat Res Ctr Excellence, Res & Innovat Inst Excellence, Nakhon Si Thammarat 80160, Thailand

[3] Chiang Mai Univ, Fac Pharm, Chiang Mai 50200, Thailand

[4] Chiang Mai Univ, Off Res Adm, Chiang Mai 50200, Thailand

[5] Syracuse Univ, Coll Engn & Comp Sci, Dept Biomed & Chem Engn, Syracuse, NY 13244 USA

[6] Walailak Univ, Sch Pharm, Nakhon Si Thammarat 80160, Thailand

[7] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Food & Pharmaceut Chem, Bangkok 10330, Thailand

[8] Ramkhamhang Univ, Dept Chem, Bangkok 10240, Thailand

[9] Ramkhamhang Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok 10240, Thailand

[10] Walailak Univ, Sch Agr Technol & Food Ind, Nakhon Si Thammarat 80160, Thailand

来源：

NANOMEDICINE | 2024年 / 19卷 / 14期

关键词：

anti-inflammation; curcumin; keratinocyte migration; nanovesicles; scaffold; tetrahydrocurcumin; IN-VITRO; INFLAMMATION; RELEASE; ANALOGS;

D O I：

10.1080/17435889.2024.2347823

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Polymeric scaffolds were developed fortified with nanovesicle-encapsulated individual curcumin (CUR) and tetrahydrocurcumin (THC) for improved therapeutic efficacy due to their low stability and efficacy in native form. Method: Nanovesicle-encapsulated individual CUR and THC were fabricated using thin-film hydration techniques and characterized. Results & conclusion: CUR/THC in native and vesicle-encapsulated form demonstrated diminished LPS-instigate nitric oxide (NO) levels in macrophage cells in a concentration-dependent demeanor. However, vesicle-encapsulated CUR/THC inhibited NO production at lower concentrations, compared with the native CUR/THC form. Furthermore, the scaffold fortified with vesicle-encapsulated CUR/THC demonstrated improved physical properties with excellent antioxidant, biocompatibility, and human keratinocyte cell proliferation ability. The results recommended that nanovesicle-encapsulated THC can be retained as a potential substitute for CUR with improved therapeutic efficacy. [GRAPHICS] .

引用

页码：1313 / 1329

页数：17

共 58 条

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