Involvement of Nrf2 Signaling in Lead-induced Toxicity

被引：5

作者：

Arabnezhad, Mohammad-Reza ^{[1
]}

Haghani, Fatemeh ^{[2
]}

Ghaffarian-Bahraman, Ali ^{[3
]}

Jafarzadeh, Emad ^{[4
]}

Mohammadi, Hamidreza ^{[5
]}

Yadegari, Javad Ghasemian ^{[6
]}

Farkhondeh, Tahereh ^{[7
]}

Aschner, Michael ^{[8
]}

Darroudi, Majid ^{[9
]}

Marouzi, Somayeh ^{[10
,11
]}

Samarghandian, Saeed ^{[12
]}

机构：

[1] Kerman Univ Med Sci, Fac Pharm, Dept Toxicol & Pharmacol, Kerman, Iran

[2] Kerman Univ Med Sci, Fac Pharm, Dept Pharmaceut Biotechnol, Kerman, Iran

[3] Rafsanjan Univ Med Sci, Occupat Environm Res Ctr, Rafsanjan, Iran

[4] Univ Tehran Med Sci, Fac Pharm, Dept Toxicol & Pharmacol, Tehran, Iran

[5] Lorestan Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Khorramabad, Iran

[6] Lorestan Univ Med Sci, Fac Pharm, Dept Pharmacognosy, Khorramabad, Iran

[7] Birjand Univ Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Birjand, Iran

[8] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[9] Mashhad Univ Med Sci, Nucl Med Res Ctr, Mashhad, Iran

[10] Neyshabur Univ Med Sci, Dept Basic Med Sci, Neyshabur, Iran

[11] Mashhad Univ Med Sci, Fac Med, Dept Med Biotechnol & Nanotechnol, Mashhad, Iran

[12] Neyshabur Univ Med Sci, Healthy Ageing Res Ctr, Neyshabur 9318614139, Iran

来源：

CURRENT MEDICINAL CHEMISTRY | 2024年 / 31卷 / 23期

关键词：

Nrf2; pathway; lead; Pb; oxidative stress; carcinogenesis; toxicity; TRANSCRIPTION FACTOR NRF2; INDUCED OXIDATIVE STRESS; CHRONIC RENAL-DISEASES; HEAVY-METALS; ENVIRONMENTAL EXPOSURE; KEAP1-NRF2; PATHWAY; NEUROLOGICAL DEFICITS; MOLECULAR-MECHANISMS; INDUCED HYPERTENSION; NATIONAL-HEALTH;

D O I：

10.2174/0929867330666230522143341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear factor erythroid 2-related factor 2 (Nrf2) is used as one of the main protective factors against various pathological processes, as it regulates cells resistant to oxidation. Several studies have extensively explored the relationship between environmental exposure to heavy metals, particularly lead (Pb), and the development of various human diseases. These metals have been reported to be able to, directly and indirectly, induce the production of reactive oxygen species (ROS) and cause oxidative stress in various organs. Since Nrf2 signaling is important in maintaining redox status, it has a dual role depending on the specific biological context. On the one hand, Nrf2 provides a protective mechanism against metal-induced toxicity; on the other hand, it can induce metal-induced carcinogenesis upon prolonged exposure and activation. Therefore, the aim of this review was to summarize the latest knowledge on the functional interrelation between toxic metals, such as Pb and Nrf2 signaling.

引用

页码：3529 / 3549

页数：21

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