Lymphedema: Pathogenesis and Novel Therapies

被引:109
作者
Dayan, Joseph H. [1 ,2 ]
Ly, Catherine L. [1 ]
Kataru, Raghu P. [1 ]
Mehrara, Babak J. [1 ,2 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Surg, Plast & Reconstruct Surg Serv, New York, NY 10065 USA
[2] Weill Cornell Med Coll, Dept Surg, Plast & Reconstruct Surg Serv, New York, NY 10065 USA
来源
ANNUAL REVIEW OF MEDICINE, VOL 69 | 2018年 / 69卷
关键词
CD4(+) cells; complete decongestive therapy; lymphovenous bypass; lymph node transfer; CANCER-RELATED LYMPHEDEMA; HEALING APPROACH LYMPHA; LEVEL LASER THERAPY; BREAST-CANCER; PERIPHERAL LYMPHEDEMA; COMPRESSION THERAPY; ARM LYMPHEDEMA; STROMAL CELLS; NODE TRANSFER; STEM-CELLS;
D O I
10.1146/annurev-med-060116-022900
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Lymphedema affects up to 1 in 6 patients who undergo treatment for a solid tumor in the United States. Its prevalence has increased as more effective oncologic therapies have improved patient survival, but there remains no definitive cure. Recent research has elucidated new details in the pathogenesis of the disease and has demonstrated that it is fundamentally an immunologic process that ultimately results in inflammation, fibroadipose deposition, impaired lymphangiogenesis, and dysfunctional lymphatic pumping. These findings have allowed for the development of novel medical and surgical therapies that may potentially alter the standard of care for a disease that has largely been treated by compression. This review seeks to provide an overview of the emerging therapies and how they can be utilized for effective management of lymphedema.
引用
收藏
页码:263 / 276
页数:14
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