Multiscale biomedical imaging at the SYRMEP beamline of Elettra - Closing the gap between preclinical research and patient applications

被引：25

作者：

Dullin, Christian ^{[1
,2
,5
]}

di Lillo, Francesca ^{[3
]}

Svetlove, Angelika ^{[1
]}

Albers, Jonas ^{[1
]}

Wagner, Willi ^{[2
,4
]}

Markus, Andrea ^{[5
]}

Sodini, Nicola ^{[3
]}

Dreossi, Diego ^{[3
]}

Alves, Frauke ^{[1
,5
,6
]}

Tromba, Giuliana ^{[3
]}

机构：

[1] Univ Med Ctr Goettingen, Inst Diagnost & Intervent Radiol, Gottingen, Germany

[2] Univ Hosp Heidelberg, Diagnost & Intervent Radiol, Heidelberg, Germany

[3] Elettra Sincrotrone Trieste, Trieste, Italy

[4] Heidelberg Univ, Translat Lung Res Ctr TLRC, German Ctr Lung Res DZL, Heidelberg, Germany

[5] Max Plank Inst Expt Med, Gottingen, Germany

[6] Univ Med Ctr Goettingen, Inst Haematol & Med Oncol, Gottingen, Germany

来源：

PHYSICS OPEN | 2021年 / 6卷

关键词：

Synchrotron radiation; Propagation based imaging; Phase; -contrast; Biomedical imaging; CONTRAST COMPUTED-TOMOGRAPHY; SYNCHROTRON-RADIATION; LUNGS; QUANTIFICATION; OPTIMIZATION; MICROCT; MODELS; CELLS; MICE;

D O I：

10.1016/j.physo.2020.100050

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Here we present the specifications and capabilities of the SYRMEP (SYnchrotron Radiation for MEdical Physics) beamline of the Italian Synchrotron "Elettra" in Trieste. SYRMEP was designed to provide X-ray imaging in an energy range that fits both biomedical research and clinical applications on patients. Additionally, SYRMEP covers a spatial resolution range of 100 mu m down to 1 mu m (1/50th the width of a human hair) with a comparably wide field-of-view (FOV), which enables studies in large specimens and therefore closes the gap between micro computed tomography (CT) in biomedical research and clinical CT imaging. Moreover, the possible long sampleto-detector distance allows for an effective use of free-propagation phase contrast that increases dose efficacy and soft-tissue contrast. These parameters and their function are further discussed on a set of examples of biomedical applications.

引用

页数：9

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