Pleiotropic attenuating effect of Ginkgo biloba against isoprenaline-induced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na+, K+-ATPase activities

被引:10
作者
Asiwe, Jerome Ndudi [1 ,2 ]
Ojetola, Abodunrin Adebayo [3 ]
Ekene, Nwoke Enekabokom [4 ]
Osirim, Esthinsheen [5 ]
Nnamudi, Anthony Chibuzor [6 ]
Oritsemuelebi, Benjamin [7 ]
Onuelu, Jackson Erozueme [7 ]
Asiwe, Nicholas [8 ]
Eruotor, Harrison Ogheneochuko [9 ]
Inegbenehi, Saviour [6 ]
机构
[1] Delta State Univ, Dept Physiol, Abraka, Nigeria
[2] Univ Ibadan, Dept Physiol, Ibadan 3017, Nigeria
[3] Adeleke Univ, Dept Physiol, Ede 250, Nigeria
[4] Rivers State Univ, Dept Pharmacol, Nkpolu Oroworukwo 5080, Nigeria
[5] Redeemers Univ, Dept Physiol, Ede 230, Nigeria
[6] PAMO Univ Med Sci, Dept Biochem, Port Harcourt 500211, Nigeria
[7] Delta State Univ, Dept Pharmacol, Abraka, Nigeria
[8] Univ Port Harcourt, Dept Anat, Choba 5323, Nigeria
[9] Univ Port Harcourt, Dept Med Lab Sci, Choba 5323, Nigeria
关键词
antioxidants; extracellular signal-regulated kinase; Ginkgo biloba extract; isoprenaline; mammalian target of rapamycin; myocardial infarction; Na+; K+-ATPase; OXIDATIVE STRESS;
D O I
10.1016/j.chmed.2023.11.001
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Objective: Myocardial infarction (MI) is linked to an imbalance in the supply and demand of blood oxygen in the heart muscles. Beta-blockers and calcium antagonists are just two of the common medications used to treat MI. However, these have reportedly been shown to be either ineffective or to have undesirable side effects. Extract of Ginkgo biloba leaves (GBE), a Chinese herbal product offers special compatibility benefits in therapeutic settings relating to inflammatory diseases and oxidative stress. In order to better understand how GBE affects MI in rats insulted by isoprenaline (ISO), the current study was designed. Methods: The heart weight index, serum lipid profile, cardiac marker enzymes, endogenous antioxidants [catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), nitrites and malondialdehyde (MDA)], inflammatory mediators [tumour necrosis factor alpha (TNF-a) and interleukin-6 (IL-6)], immunohistochemical expressions of B-cell lymphoma factor-2 (Bcl-2), extracellular signal-regulated kinase (ERK1/2), and mammalian target of rapamycin (mTOR) and histopathological analysis were used to assess the cardioprotective properties of GBE. Results: The findings showed that GBE effectively attenuated myocardial infarction by boosting the body's natural antioxidant defense system and reducing the release of inflammatory cytokines as well as heart injury marker enzymes. The expression of Bcl-2, ERK1/2 and mTOR was increased while the histomorphological alterations were reversed. Conclusion: The cardioprotective effects of GBE may be due to a mechanism involving increased Bcl-2/ mTOR/ERK1/2/Na+, K+-ATPase activity. (c) 2024 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:282 / 292
页数:11
相关论文
共 94 条
  • [1] Adebayo O.G., 2023, Phytomedicine, V3
  • [2] Ginkgo biloba protects striatal neurodegeneration and gut phagoinflammatory damage in rotenone-induced mice model of Parkinson's disease: Role of executioner caspase-3/Nrf2/ARE signaling
    Adebayo, Olusegun G.
    Asiwe, Jerome N.
    Ben-Azu, Benneth
    Aduema, Wadioni
    Onyeleonu, Ijeoma
    Akpotu, Ajirioghene E.
    Wopara, Iheanyichukwu
    Kolawole, Tolunigba A.
    Umoren, Elizabeth B.
    Igbokwe, Vincent
    Buduburisi, Buduchim R.
    Onwuka, Favour C.
    Brown, Providence I.
    [J]. JOURNAL OF FOOD BIOCHEMISTRY, 2022, 46 (09)
  • [3] Alawode D. I., 2021, Int J Nutr Sci, V6, P155, DOI [10.30476/IJNS.2021.92067.1145, DOI 10.30476/IJNS.2021.92067.1145]
  • [4] Myocardial infarction and oxidative damage in animal models: objective and expectations from the application of cysteine derivatives
    Angelovski, Marija
    Hadzi-Petrushev, Nikola
    Mitrokhin, Vadim
    Kamkin, Andre
    Mladenov, Mitko
    [J]. TOXICOLOGY MECHANISMS AND METHODS, 2023, 33 (01) : 1 - 17
  • [5] Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review
    Anik, Muzahidul I.
    Mahmud, Niaz
    Al Masud, Abdullah
    Khan, Md Ishak
    Islam, Md Nurul
    Uddin, Shihab
    Hossain, M. Khalid
    [J]. ACS APPLIED BIO MATERIALS, 2022, 5 (09) : 4028 - 4054
  • [6] Asiwe J.N., 2023, Pharmacological Research-Modern Chinese Medicine, V8
  • [7] Ginkgo biloba supplement abates lead-induced endothelial and testicular dysfunction in Wistar rats via up-regulation of Bcl-2 protein expression, pituitary-testicular hormones and down-regulation of oxido-inflammatory reactions
    Asiwe, Jerome Ndudi
    Ekene, Enekabokom Nwoke
    Agbugba, Linda Chinyere
    Moke, Emuesiri Goodies
    Akintade, Abimbola Victoria
    Ben-Azu, Benneth
    Eruotor, Harrison
    Daubry, Tarela Melish Elias
    Anachuna, Kenneth Kelechi
    Oyovwi, Mega O.
    [J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2023, 79
  • [8] Ginkgo biloba modulates ET-I/NO signalling in Lead Acetate induced rat model of endothelial dysfunction: Involvement of oxido-inflammatory mediators
    Asiwe, Jerome Ndudi
    Yovwin, Godwin D.
    Ekene, Nwoke Enekabokom
    Ovuakporaye, Simon Irikefe
    Nnamudi, Anthony Chibuzor
    Nwangwa, Eze Kingsley
    [J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, 2024, 34 (02) : 979 - 990
  • [9] Up-regulation of B-cell lymphoma factor-2 expression, inhibition of oxidative stress and down-regulation of pro-inflammatory cytokines are involved in the protective effect of cabbage (Brassica oleracea) juice in lead-induced endothelial dysfunction in rats
    Asiwe, Jerome Ndudi
    Kolawole, Tolunigba Abisola
    Ben-Azu, Benneth
    Ajayi, Abayomi Mayowa
    Ojetola, Abodunrin Adebayo
    Moke, Emuesiri Goodies
    Nwangwa, Eze Kingsley
    [J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2022, 73
  • [10] Ginkgo biloba Supplement Reverses Lead (II) Acetate-Induced Haematological Imbalances, and Hepatic and Renal Dysfunctions in Male Wistar Rat
    Asiwe, Jerome Ndudi
    Daubry, Tarela Melish Elias
    Okon, Idara Asuquo
    Akpotu, Ajirioghene Emamuzou
    Adagbada, Ebunoluwa Oluwabusola
    Eruotor, Harrison
    Agbugba, Linda Chinyere
    Buduburisi, Buduchim Rejoice
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 2022, 200 (12) : 5134 - 5144