Impact of sociodemographic status and sex on chronic rhinosinusitis and olfaction in people with cystic fibrosis

被引：0

作者：

Han, Ethan J. ^{[1
]}

Liu, Christine M. ^{[1
]}

Fischer, Jakob L. ^{[1
]}

Mace, Jess C. ^{[2
]}

Markarian, Karolin ^{[3
]}

Alt, Jeremiah A. ^{[4
]}

Bodner, Todd E. ^{[5
]}

Chowdhury, Naweed I. ^{[6
]}

Eshaghian, Patricia H. ^{[7
]}

Gao, Yuqing A. ^{[7
]}

Getz, Anne E. ^{[8
]}

Hwang, Peter H. ^{[9
]}

Khanwalkar, Ashoke ^{[8
]}

Kimple, Adam J. ^{[10
]}

Lee, Jivianne T. ^{[1
]}

Li, Douglas A. ^{[7
]}

Norris, Meghan ^{[10
]}

Nayak, Jayakar V. ^{[9
]}

Owens, Cameran ^{[10
]}

Patel, Zara M. ^{[9
]}

Poch, Katie ^{[11
]}

Schlosser, Rodney J. ^{[12
]}

Smith, Kristine A. ^{[4
]}

Smith, Timothy L. ^{[2
]}

Soler, Zachary M. ^{[12
]}

Suh, Jeffrey D. ^{[1
]}

Turner, Grant A. ^{[7
]}

Wang, Marilene B. ^{[1
]}

Taylor-Cousar, Jennifer L. ^{[11
,13
]}

Saavedra, Milene T. ^{[11
]}

Beswick, Daniel M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Head & Neck Surg, 10833 Conte Ave,CHS 62-235, Los Angeles, CA 90095 USA

[2] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, CTSI, Los Angeles, CA USA

[4] Univ Utah, Dept Otolaryngol Head & Neck Surg, Salt Lake City, UT USA

[5] Portland State Univ, Dept Psychol, Portland, OR USA

[6] Vanderbilt Univ Sch Med, Dept Otolaryngol Head & Neck Surg, Nashville, TN USA

[7] Univ Calif Los Angeles, Dept Pulm Med, Los Angeles, CA USA

[8] Univ Colorado, Dept Otolaryngol Head & Neck Surg, Denver, CO USA

[9] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Stanford, CA USA

[10] Univ North Carolina Chapel Hill, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC USA

[11] Natl Jewish Hlth, Dept Med, Denver, CO USA

[12] Med Univ South Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC USA

[13] Natl Jewish Hlth, Dept Pediat, Denver, CO USA

来源：

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY | 2024年 / 14卷 / 11期

基金：

美国国家卫生研究院;

关键词：

chronic rhinosinusitis; cystic fibrosis; patient symptoms; socioeconomic status; QUALITY-OF-LIFE; SOCIOECONOMIC-STATUS; OUTCOMES; ASSOCIATION; GENDER;

D O I：

10.1002/alr.23402

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: Sociodemographic status (SDS) including race/ethnicity and socioeconomic status as approximated by education, income, and insurance status impact pulmonary disease in people with cystic fibrosis (PwCF). The relationship between SDS and chronic rhinosinusitis (CRS) remains understudied. Methods: In a prospective, multi-institutional study, adult PwCF completed the 22-Question SinoNasal Outcome Test (SNOT-22), Smell Identification Test (SIT), Questionnaire of Olfactory Disorder Negative Statements (QOD-NS), and Cystic Fibrosis Questionnaire-Revised (CFQ-R). Lund-Kennedy scores, sinus computed tomography, and clinical data were collected. Data were analyzed across race/ethnicity, sex, and socioeconomic factors using multivariate regression. Results: Seventy-three PwCF participated with a mean age of 34.7 +/- 10.9 years and 49 (67.1%) were female. Linear regression identified that elexacaftor/tezacaftor/ivacaftor (ETI) use (beta = -4.09, 95% confidence interval [CI] [-6.08, -2.11], p < 0.001), female sex (beta = -2.14, 95% CI [-4.11, -0.17], p = 0.034), and increasing age (beta = -0.14, 95% CI [-0.22, -0.05], p = 0.003) were associated with lower/better endoscopy scores. Private health insurance (beta = 17.76, 95% CI [5.20, 30.32], p = 0.006) and >16 educational years (beta = 13.50, 95% CI [2.21, 24.80], p = 0.020) were associated with higher baseline percent predicted forced expiratory volume in one second (ppFEV1). Medicaid/Medicare insurance was associated with worse endoscopy scores, CFQ-R respiratory scores, and ppFEV1 (all p < 0.017), and Hispanic/Latino ethnicity was associated with worse SNOT-22 scores (p = 0.047), prior to adjustment for other cofactors. No other SDS factors were associated with SNOT-22, QOD-NS, or SIT scores. Conclusions: Differences in objective measures of CRS severity exist among PwCF related to sex, age, and ETI use. Variant status and race did not influence patient-reported CRS severity measures or olfaction in this study. Understanding how these factors impact response to treatment may improve care disparities among PwCF. Clinical TrialsNCT04469439

引用

页码：1700 / 1713

页数：14

共 50 条

[21] Chronic rhinosinusitis in cystic fibrosis: a review of therapeutic options
Krajewska, Joanna
Zub, Krzysztof
Slowikowski, Adam
Zatonski, Tomasz
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2022, 279 (01) : 1 - 24
[22] Chronic rhinosinusitis in cystic fibrosis: a review of therapeutic options
Joanna Krajewska
Krzysztof Zub
Adam Słowikowski
Tomasz Zatoński
European Archives of Oto-Rhino-Laryngology, 2022, 279 : 1 - 24
[23] Chronic rhinosinusitis and cystic fibrosis: the interaction between sinus bacteria and mucosal immunity
Kim, Raymond J. T.
Park, Lydia
Wood, Andrew J.
Yin, Tary
Jain, Ravi
Douglas, Richard G.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 2015, 5 (05) : 380 - 385
[24] The management of cystic fibrosis chronic rhinosinusitis: An evidenced-based review with recommendations
Spielman, Daniel B.
Beswick, Daniel M.
Kimple, Adam J.
Senior, Brent A.
Aanaes, Kasper
Woodworth, Bradford A.
Schlosser, Rodney J.
Lee, Stella
Cho, Do-Yeon
Adappa, Nithin D.
DiMango, Emily
Gudis, David A.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 2022, 12 (09) : 1148 - 1183
[25] National Trends in Chronic Rhinosinusitis and Inpatient Sinus Surgery in Adults with Cystic Fibrosis
Qu, Roy W.
Punjabi, Nihal
Lao, Wilson P.
Seiberling, Kristin A.
Church, Christopher A.
OTO OPEN, 2025, 9 (01)
[26] Glandular Gene Expression of Sinus Mucosa in Chronic Rhinosinusitis with and without Cystic Fibrosis
Wu, Xiaofang
Peters-Hall, Jennifer R.
Ghimbovschi, Svetlana
Mimms, Remy
Rose, Mary C.
Pena, Maria T.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2011, 45 (03) : 525 - 533
[27] Correlations Between Cystic Fibrosis Genotype and Sinus Disease Severity in Chronic Rhinosinusitis
Abuzeid, Waleed M.
Song, Changeun
Fastenberg, Judd H.
Fang, Christina H.
Ayoub, Noel
Jerschow, Elina
Mohabir, Paul K.
Hwang, Peter H.
LARYNGOSCOPE, 2018, 128 (08) : 1752 - 1758
[28] Sex Differences After Treatment With Ivacaftor in People With Cystic Fibrosis
Holtrop, Melanie
Cosmich, Sophia
Lee, MinJae
Keller, Ashley
Jain, Raksha
CHEST, 2024, 166 (05) : 951 - 962
[29] The criteria for chronic rhinosinusitis in children with cystic fibrosis are rarely fulfilled after initiation of CFTR modulator treatment
Bech, Magne
Skov, Marianne
Andersen, Ida S. B.
von Buchwald, Christian
Aanaes, Kasper
APMIS, 2024, 132 (09) : 625 - 631
[30] Chronic rhinosinusitis in people with cystic fibrosis-an up-to-date review from the perspective of otorhinolaryngology
Topcuoglu, M. Yilmaz
Sommerburg, O.
Wielpuetz, M. O.
Wucherpfennig, L.
Hackenberg, S.
Mainz, J. G.
Baumann, I.
HNO, 2024,

← 1 2 3 4 5 →