Long non-coding RNA HOTAIR: A biomarker and therapeutic target in urological tumors

被引：0

作者：

Abida

Eltaib, Lina ^{[2
]}

Alhazmi, Bshayer Hmdan ^{[3
]}

Alzahrani, Abdullah R. ^{[4
]}

Asdaq, Syed Mohammed Basheeruddin ^{[5
]}

Ali, Abuzer ^{[6
]}

Aldhafiri, Futoon Jamal ^{[7
]}

Alruwaili, Wafaa T. ^{[7
]}

Al-Hajeili, Marwan ^{[8
]}

Abdulkhaliq, Altaf A. ^{[9
]}

Rabaan, Ali A. ^{[10
,11
,12
]}

Imran, Mohd ^{[1
,13
]}

机构：

[1] Northern Border Univ, Coll Pharm, Dept Pharmaceut Chem, Rafha 91911, Saudi Arabia

[2] Northern Border Univ, Coll Pharm, Dept Pharmaceut, Rafha 91911, Saudi Arabia

[3] Northern Area Armed Forces Hosp, Dept Pharm, Hafer Al Batin 39745, Saudi Arabia

[4] Umm Al Qura Univ, Fac Med, Dept Pharmacol & Toxicol, POB 13578, Mecca 21955, Saudi Arabia

[5] AlMaarefa Univ, Coll Pharm, Dept Pharm Practice, Riyadh 13713, Saudi Arabia

[6] Taif Univ, Coll Pharm, Dept Pharmacognosy, POB 11099, Taif 21944, Saudi Arabia

[7] Northern Border Univ, Coll Pharm, Rafha 91911, Saudi Arabia

[8] King Abdulaziz Univ, Dept Med, Jeddah 23624, Saudi Arabia

[9] Umm Al Qura Univ, Fac Med, Dept Biochem, Mecca 21955, Saudi Arabia

[10] Johns Hopkins Aramco Healthcare, Mol Diagnost Lab, Dhahran 31311, Saudi Arabia

[11] Alfaisal Univ, Coll Med, Riyadh 11533, Saudi Arabia

[12] Univ Haripur, Dept Publ Hlth & Nutr, Haripur 22610, Pakistan

[13] Northern Border Univ, Ctr Hlth Res, Ar Ar, Saudi Arabia

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 262卷

关键词：

HOTAIR; Urologic cancer; Kidney; Bladder; Long non coding RNA; PROSTATE-CANCER; LNCRNA HOTAIR; UP-REGULATION; ENHANCES RADIOSENSITIVITY; DRUG-RESISTANCE; LUNG-CANCER; CHROMATIN; TRANSCRIPTION; PRC2; LANDSCAPE;

D O I：

10.1016/j.prp.2024.155549

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Long non-coding RNAs (lncRNAs) significantly influence gene regulation across epigenetic, transcriptional, and post-transcriptional levels through their interactions with DNA, RNA, and proteins. There is growing evidence of lncRNAs' critical roles in the emergence and progression of various diseases, including urological tumors (UTs), such as cancers of the kidney, bladder, and prostate. Research increasingly links lncRNA dysregulation to diverse cellular processes like invasion, metastasis, apoptosis, and chromatin remodeling. Among these, HOTAIR stands out for its pivotal role in oncogenesis, impacting treatment resistance, cell migration, proliferation, survival, and genomic integrity. This review provides an overview of HOTAIR's functions, its identification, and its biological significance. Furthermore, it delves into HOTAIR's involvement in UTs, underlining its potential as a therapeutic target and biomarker for innovative approaches to treating these cancers.

引用

页数：10

共 50 条

[41] Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease
Syamantak Majumder
Mitchell J. Hadden
Karina Thieme
Sri N. Batchu
Divya Niveditha
Shibasish Chowdhury
Veera Ganesh Yerra
Suzanne L. Advani
Bridgit B. Bowskill
Youan Liu
Hana Vakili
Tamadher A. Alghamdi
Kathryn E. White
Laurette Geldenhuys
Ferhan S. Siddiqi
Andrew Advani
Diabetologia, 2019, 62 : 2129 - 2142
[42] Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues
Hajjari, Mohammadreza
Behmanesh, Mehrdad
Sadeghizadeh, Majid
Zeinoddini, Mehdi
MEDICAL ONCOLOGY, 2013, 30 (03)
[43] Long non-coding RNA HOTAIR promotes carcinogenesis and invasion of gastric adenocarcinoma
Lee, Na Keum
Lee, Jung Hwa
Park, Chan Hyuk
Yu, Dayeon
Lee, Yong Chan
Cheong, Jae-Ho
Noh, Sung Hoon
Lee, Sang Kil
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 451 (02) : 171 - 178
[44] Long non-coding RNA CCAT2 as a therapeutic target in colorectal cancer
Fosselteder, Johannes
Calin, George A.
Pichler, Martin
EXPERT OPINION ON THERAPEUTIC TARGETS, 2018, 22 (12) : 973 - 976
[45] Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues
Mohammadreza Hajjari
Mehrdad Behmanesh
Majid Sadeghizadeh
Mehdi Zeinoddini
Medical Oncology, 2013, 30
[46] Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease
Majumder, Syamantak
Hadden, Mitchell J.
Thieme, Karina
Batchu, Sri N.
Niveditha, Divya
Chowdhury, Shibasish
Yerra, Veera Ganesh
Advani, Suzanne L.
Bowskill, Bridgit B.
Liu, Youan
Vakili, Hana
Alghamdi, Tamadher A.
White, Kathryn E.
Geldenhuys, Laurette
Siddiqi, Ferhan S.
Advani, Andrew
DIABETOLOGIA, 2019, 62 (11) : 2129 - 2142
[47] The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget
Ahmad, Faraz
Sudesh, Ravi
Ahmed, Atheeq Toufeeq
Arumugam, Mohanapriya
Mathkor, Darin Mansor
Haque, Shafiul
EXPERT REVIEWS IN MOLECULAR MEDICINE, 2024, 26
[48] HOTAIR, A Long Non-Coding RNA, Is a Marker of Abnormal Cell Cycle Regulation in Lung Cancer
Liu, M.
Ren, F.
Li, X.
Zhang, H.
Chen, J.
JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (12) : S1073 - S1073
[49] Long Non-coding RNA: An Emerging Contributor and Potential Therapeutic Target in Renal Fibrosis
Xia, Weiping
He, Yao
Gan, Yu
Zhang, Bo
Dai, Guoyu
Ru, Feng
Jiang, Zexiang
Chen, Zhi
Chen, Xiang
FRONTIERS IN GENETICS, 2021, 12
[50] HOTAIR but not ANRIL long non-coding RNA contributes to the pathogenesis of multiple sclerosis
Kakhki, Majid Pahlevan
Nikravesh, Abbas
Farsani, Zeinab Shirvani
Sahraian, Mohammad Ali
Behmanesh, Mehrdad
IMMUNOLOGY, 2018, 153 (04) : 479 - 487

← 1 2 3 4 5 →