Recent Approaches on Molecular Markers, Treatment and Novel Drug Delivery System Used for the Management of Colorectal Cancer: A Comprehensive Review

被引:1
|
作者
Chauhan, Sonia [1 ]
Sharma, Sakshi [1 ]
机构
[1] Noida Inst Engn & Technol, Pharm Inst, Greater Noida 201306, Uttar Pradesh, India
关键词
PVT1; colorectal cancer; diagnosis; biomarkers; carcinoma; mutation; antibody; gene expression; PH-SENSITIVE NANOPARTICLES; POLYMERIC NANOPARTICLES; THERAPEUTIC STRATEGIES; ULCERATIVE-COLITIS; TARGETED THERAPY; GENE-THERAPY; IN-VITRO; BIOMARKER; KRAS; COMBINATION;
D O I
10.2174/0113892010270975231208113157
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Colorectal cancer affects 1 in 25 females and 1 in 24 males, making it the third most frequent cancer with over 6,08,030 deaths worldwide, despite advancements in detection and treatments, including surgery, chemotherapeutics, radiotherapy, and immune therapeutics. Novel potential agents have increased survival in acute and chronic disease conditions, with a higher risk of side effects and cost. However, metastatic disease has an insignificant long-term diagnosis, and significant challenges remain due to last-stage diagnosis and treatment failure. Early detection, survival, and treatment efficacy are all improved by biomarkers. The advancement of cancer biomarkers' molecular pathology and genomics during the last three decades has improved therapy. Clinically useful prognostic biomarkers assist clinical judgment, for example, by predicting the success of EGFR-inhibiting antibodies in the presence of KRAS gene mutations. Few biomarkers are currently used in clinical settings, so further research is still needed. Nanocarriers, with materials like Carbon nanotubes and gold nanoparticles, provide targeted CRC drug delivery and diagnostics. Light-responsive drugs with gold and silica nanoparticles effectively target and destroy CRC cells. We evaluate the potential use of the long non-coding RNA (non-coding RNA) oncogene plasmacytoma variant translocation 1 (PVT1) as a diagnostic, prognostic, and therapeutic biomarker, along with the latest nanotech breakthroughs in CRC diagnosis and treatment.
引用
收藏
页码:1969 / 1985
页数:17
相关论文
共 50 条
  • [31] Colorectal Cancer: Risk Factors, Novel Approaches in Molecular Screening and Treatment
    Anbari, Khatereh
    Ghanadi, Koroush
    INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 2025, 14 (01) : 1 - 30
  • [32] Nanoengineered approaches to improve the efficacy of targeted drug delivery for the treatment of malignancy: a comprehensive review
    Bag, Jagabandhu
    Banerjee, Sabyasachi
    De, Arnab
    Manna, Sreejan
    Banerjee, Subhasis
    Kumar, S. K. Ashok
    De, Sourav
    FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 9 (01)
  • [33] Nanoengineered approaches to improve the efficacy of targeted drug delivery for the treatment of malignancy: a comprehensive review
    Jagabandhu Bag
    Sabyasachi Banerjee
    Arnab De
    Sreejan Manna
    Subhasis Banerjee
    S. K. Ashok Kumar
    Sourav De
    Future Journal of Pharmaceutical Sciences, 9
  • [34] Molecular targeted treatment and drug delivery system for gastric cancer
    Lanxin Jiang
    Xiaomin Gong
    Wangdi Liao
    Nonghua Lv
    Runwei Yan
    Journal of Cancer Research and Clinical Oncology, 2021, 147 : 973 - 986
  • [35] Molecular targeted treatment and drug delivery system for gastric cancer
    Jiang, Lanxin
    Gong, Xiaomin
    Liao, Wangdi
    Lv, Nonghua
    Yan, Runwei
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2021, 147 (04) : 973 - 986
  • [36] Advances in the management of childhood gliomas: Molecular markers of prognosis and novel treatment approaches
    Pollack, I
    NEURO-ONCOLOGY, 2005, 7 (03) : 348 - 348
  • [37] EMULGEL-NOVEL TOPICAL DRUG DELIVERY SYSTEM-A COMPREHENSIVE REVIEW
    Kumar, Davinder
    Singh, Jasbir
    Antil, Mamta
    Kumar, Virender
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2016, 7 (12): : 4733 - 4742
  • [38] Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review
    Osorio, Marlon
    Martinez, Estefania
    Naranjo, Tonny
    Castro, Cristina
    MOLECULES, 2020, 25 (10):
  • [39] A Comprehensive Review on Nanoparticles as a Targeted Delivery System for the Treatment of Lung Cancer
    Gupta, Twinkle
    Varanwal, Avinash
    Nema, Priyanshu
    Soni, Sakshi
    Iyer, Arun Kumar
    Das, Ratnesh
    Soni, Vandana
    Kashaw, Sushil Kumar
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2024, 24 (03) : 157 - 168
  • [40] Effects of molecular markers on the treatment decision and prognosis of colorectal cancer: a narrative review
    Cao, Yujuan
    Wang, Xiaodong
    JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2021, 12 (03) : 1191 - 1196