Animal models used in meniscal repair research from ex vivo to in vivo: A systematic review

被引:0
|
作者
Mazy, David [1 ,2 ]
Lu, Daisy [3 ]
Leclerc, Sebastien [3 ]
Laor, Boaz [4 ]
Wang, Jessica [3 ]
Pinvicy, Alix [1 ]
Moldovan, Florina [3 ]
Nault, Marie-Lyne [1 ,2 ,5 ,6 ]
机构
[1] CHU St Justine, 7905-3175 Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada
[2] Univ Montreal, Dept Surg, 2900 Boul Edouard Montpetit, Montreal, PQ H3T 1J4, Canada
[3] CHU St Justine, Azrieli Res Ctr, 7905-3175 Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada
[4] McGill Univ, Fac Med, 1650 Cedar Ave, Montreal, PQ H3G 1A4, Canada
[5] CIUSSS Hop Sacre oeur Montreal HSCM, Dept Orthoped Surg, 5400 Boul Gouin Ouest, Montreal, PQ H4J 1C5, Canada
[6] CHU St Justine, 3175 Chemin Cote St Catherine, Montreal, PQ H3T 1C5, Canada
关键词
Meniscal repair; Animal model; Orthopaedic research; Meniscal suture; Basic science; Knee surgery; TIBIOFEMORAL CONTACT MECHANICS; PULL-OUT REPAIR; ALL-INSIDE; BIOMECHANICAL EVALUATION; MEDIAL MENISCUS; RADIAL TEARS; SUTURE TECHNIQUE; FIXATION TECHNIQUES; ROOT REPAIR; STRENGTH;
D O I
10.1016/j.jor.2024.03.038
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
This systematic review, registered with Prospero, aims to identify an optimal animal model for meniscus repair research, moving from ex vivo experimentation to in vivo studies. Data sources included PubMed, Medline, all Evidence-Based Medicine Reviews, Web of Science, and Embase searched in March 2023. Studies were screened using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Extracted data including animal model, type of experiment, type of tear, surgical techniques, and measured outcomes, were recorded, reviewed, and analyzed by four independent reviewers. The SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE) Rob tool was used for critical appraisal and risk of bias assessment. Out of 11,719 studies, 72 manuscripts were included for data extraction and analysis; 41 ex vivo extra-articular studies, 20 ex vivo intra-articular studies, and only 11 in vivo studies. Six animal models were employed: porcine, bovine, lapine, caprine, canine, and ovine. Longitudinal lesions were the most frequently studied tear pattern and sutures the most common repair technique. Studied outcomes focused mainly on biomechanical assessments and gross observations. This systematic review can guide researchers in their choice of animal model for meniscus repair research; it highlighted the strengths of the porcine, caprine, and bovine models for ex vivo cadaveric studies, while the porcine and caprine models were found to be more suited to in vivo studies due to their similarities with human anatomy. Research teams should familiarize themselves with the advantages and disadvantages of various animal models before initiating protocols to improve standardization in the field.
引用
收藏
页码:23 / 31
页数:9
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