Medial temporal lobe gray matter microstructure in preclinical Alzheimer's disease

被引：0

作者：

Brown, Christopher ^{[1
,5
]}

Das, Sandhitsu ^{[1
]}

Xie, Long ^{[2
,3
]}

Nasrallah, Ilya ^{[2
]}

Detre, John ^{[1
]}

Chen-Plotkin, Alice ^{[1
]}

Shaw, Leslie ^{[4
]}

McMillan, Corey ^{[1
]}

Yushkevich, Paul ^{[2
]}

Wolk, David ^{[1
,6
]}

机构：

[1] Univ Penn, Dept Neurol, Philadelphia, PA USA

[2] Univ Penn, Dept Radiol, Philadelphia, PA USA

[3] Siemens Healthineers, Digital Technol & Innovat, Princeton, NJ USA

[4] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA

[5] 3400 Spruce St,3 Gates, Philadelphia, PA 19104 USA

[6] Goddard 507,3710 Hamilton Walk, Philadelphia, PA 19104 USA

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; amyloid; diffusion MRI; GFAP; medial temporal lobe; microstructure; neurodegeneration; neurofibrillary tangle; PET; plasma biomarkers; tau; NEURITE ORIENTATION DISPERSION; TAU PATHOLOGY; NODDI; DENSITY; MOVEMENT; ROBUST;

D O I：

10.1002/alz.13832

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: Typical MRI measures of neurodegeneration have limited sensitivity in early disease stages. Diffusion MRI (dMRI) microstructural measures may allow for detection in preclinical stages. METHODS: Participants had dMRI and either beta-amyloid PET or plasma biomarkers of Alzheimer's pathology within 18 months of MRI. Microstructure was measured in portions of the medial temporal lobe (MTL) with high neurofibrillary tangle (NFT) burden based on a previously developed post mortem 3D-map. Regressions examined relationships between microstructure and markers of Alzheimer's pathology in preclinical disease and then across disease stages. RESULTS: There was higher isometric volume fraction in amyloid-positive compared to amyloid-negative cognitively unimpaired individuals in high tangle MTL regions. Similarly, plasma biomarkers and F-18-flortaucipir were associated with microstructural changes in preclinical disease. Additional microstructural effects were seen across disease stages. DISCUSSION: Combining a post mortem atlas of NFT pathology with microstructural measures allows for detection of neurodegeneration in preclinical Alzheimer's disease.

引用

页码：4147 / 4158

页数：12

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