Role of melatonin in carcinogenesis and metastasis: From mechanistic insights to intermeshed networks of noncoding RNAs

被引：0
|
作者：
Lin, Xiukun [1 ]
Qureshi, Muhammad Zahid [2 ]
Tahir, Fatima [3 ]
Yilmaz, Seher [4 ]
Romero, Mirna Azalea [5 ]
Attar, Rukset [6 ]
Farooqi, Ammad A. [7 ]
机构：
[1] Beibu Gulf Univ, Coll Marine Sci, Qinzhou, Guangxi, Peoples R China
[2] Qassim Univ, Coll Agr & Food, Dept Environm & Nat Resources, Buraydah, Saudi Arabia
[3] Rashid Latif Med Univ, Lahore, Pakistan
[4] Yozgat Bozok Univ, Fac Med, Dept Anat, Yozgat, Turkiye
[5] Univ Autonoma Guerrero, Fac Med, Lab Invest Clin, Acapulco, Guerrero, Mexico
[6] Yeditepe Univ Hosp, Dept Obstet & Gynecol, Istanbul, Turkiye
[7] Inst Biomed & Genet Engn IBGE, Islamabad, Pakistan
来源：
CELL BIOCHEMISTRY AND FUNCTION | 2024年 / 42卷 / 04期
关键词：
apoptosis; cancer; melatonin; metastasis; signaling; CANCER CELLS; HORMONE MELATONIN; INHIBITION; EXPRESSION; APOPTOSIS; GROWTH; SIGNATURE;
D O I：
10.1002/cbf.3995
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In recent years, seminal studies have been devoted to unraveling the puzzling mysteries associated with the cancer preventive/inhibitory role of melatonin. Our current knowledge of the translational mechanisms and the detailed structural insights have highlighted the characteristically exclusive role of melatonin in the inhibition of carcinogenesis and metastatic dissemination. This mini-review outlines recent discoveries related to mechanistic role of melatonin in prevention of carcinogenesis and metastasis. Moreover, another exciting facet of this mini-review is related to phenomenal breakthroughs linked with regulation of noncoding RNAs by melatonin in wide variety of cancers. There has been a paradigm shift in our understanding related to metamorphosis of simplistic view about melatonin from a sleep inducer to mechanistic role of melatonin in cancer prevention. Furthermore, regulation of noncoding RNAs particularly long noncoding RNAs and circular RNAs is adding another layer of complexity.
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页数：9
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