Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives

被引：4
作者：
Nandwana, Nitesh K. [1 ]
Patel, Om P. S. [2 ]
Mehra, Manish K. [1 ]
Kumar, Anil [3 ]
Salvino, Joseph M. [1 ]
机构：
[1] Wistar Inst Anat & Biol, Med Chem & Mol & Cellular Oncogenesis MCO Program, Philadelphia, PA 19104 USA
[2] Govt Polytech Naraini, Dept Tech Educ, Banda 210001, India
[3] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, India
来源：
MOLECULES | 2024年 / 29卷 / 10期
关键词：
quinazoline heterocycles; transition metal-catalyzed synthesis; C-H activation; cascade reactions; intramolecular dehydrative/dehydrogenative cyclizations; ONE-POT SYNTHESIS; AEROBIC OXIDATIVE SYNTHESIS; C-H ACTIVATION; CASCADE SYNTHESIS; 3-COMPONENT SYNTHESIS; EFFICIENT SYNTHESIS; TANDEM REACTIONS; DOMINO REACTION; DEHYDROGENATIVE SYNTHESIS; SUBSTITUTED QUINAZOLINES;
D O I：
10.3390/molecules29102353
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Quinazolines are an important class of heterocyclic compounds that have proven their significance, especially in the field of organic synthesis and medicinal chemistry because of their wide range of biological and pharmacological properties. Thus, numerous synthetic methods have been developed for the synthesis of quinazolines and their derivatives. This review article briefly outlines the new synthetic methods for compounds containing the quinazoline scaffold employing transition metal-catalyzed reactions.
引用
收藏
页数：54
相关论文
共 167 条
  • [11] Synthesis of novel 4,6-disubstituted quinazoline derivatives, their anti-inflammatory and anti-cancer activity (cytotoxic) against U937 leukemia cell lines
    Chandrika, P. Mani
    Yakaiah, T.
    Rao, A. Raghu Ram
    Narsaiah, B.
    Reddy, N. Chakra
    Sridhar, V.
    Rao, J. Venkateshwara
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (04) : 846 - 852
  • [12] Synthesis of Quinazolines via an Iron-Catalyzed Oxidative Amination of N-H Ketimines
    Chen, Cheng-yi
    He, Fengxian
    Tang, Guangrong
    Yuan, Huiqing
    Li, Ning
    Wang, Jinmin
    Faessler, Roger
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2018, 83 (04) : 2395 - 2401
  • [13] Copper-catalyzed C-N coupling/C-H functionalization: A tandem approach to azole-fused quinazoline derivatives
    Chen, Dingben
    Huang, Ling
    Yang, Jianguo
    Ma, Junna
    Zheng, Yingying
    Luo, Yi
    Shen, Yang
    Wu, Jiashou
    Feng, Chao
    Lv, Xin
    [J]. TETRAHEDRON LETTERS, 2018, 59 (21) : 2005 - 2009
  • [14] A convenient palladium-catalyzed carbonylative synthesis of quinazolines from 2-aminobenzylamine and aryl bromides
    Chen, Jianbin
    Natte, Kishore
    Neumann, Helfried
    Wu, Xiao-Feng
    [J]. RSC ADVANCES, 2014, 4 (99): : 56502 - 56505
  • [15] A Novel Ruthenium-Catalyzed Dehydrogenative Synthesis of 2-Arylquinazolines from 2-Aminoaryl Methanols and Benzonitriles
    Chen, Mengmeng
    Zhang, Min
    Xiong, Biao
    Tan, Zhenda
    Lv, Wan
    Jiang, Huanfeng
    [J]. ORGANIC LETTERS, 2014, 16 (22) : 6028 - 6031
  • [16] Unexpected Copper-Catalyzed Cascade Synthesis of Quinazoline Derivatives
    Chen, Zhongyan
    Chen, Jiuxi
    Liu, Miaochang
    Ding, Jinchang
    Gao, Wenxia
    Huang, Xiaobo
    Wu, Huayue
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2013, 78 (22) : 11342 - 11348
  • [17] Exploring Epidermal Growth Factor Receptor (EGFR) Inhibitor Features: The Role of Fused Dioxygenated Rings on the Quinazoline Scaffold
    Chilin, Adriana
    Conconi, Maria Teresa
    Marzaro, Giovanni
    Guiotto, Adriano
    Urbani, Luca
    Tonus, Francesca
    Parnigotto, Pierpaolo
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (04) : 1862 - 1866
  • [18] Crenshaw R.R., 1978, U.S. Patent, Patent No. 4098788
  • [19] Novel Substituted Quinazolines for Potent EGFR Tyrosine Kinase Inhibitors
    Cruz-Lopez, O.
    Conejo-Garcia, A.
    Nunez, M. C.
    Kimatrai, M.
    Garcia-Rubino, M. E.
    Morales, F.
    Gomez-Perez, V.
    Campos, J. M.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2011, 18 (07) : 943 - 963
  • [20] Sustainable Synthesis of Quinazoline and 2-Aminoquinoline via Dehydrogenative Coupling of 2-Aminobenzyl Alcohol and Nitrile Catalyzed by Phosphine-Free Manganese Pincer Complex
    Das, Kalicharan
    Mondal, Avijit
    Pal, Debjyoti
    Srimani, Dipankar
    [J]. ORGANIC LETTERS, 2019, 21 (09) : 3223 - 3227
12345678910