PHASE 1 STUDY OF THE CD40 AGONISTIC MONOCLONAL ANTIBODY APX005M (SOTIGALIMAB) IN PEDIATRIC, ADOLESCENT, AND YOUNG ADULT PATIENTS WITH RECURRENT OR PROGRESSIVE CNS TUMORS AND NEWLY DIAGNOSED BRAIN STEM GLIOMA: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY (PBTC-051; NCT03389802)

被引：0

作者：

Lindsay, Holly B. ^{[1
]}

Billups, Catherine ^{[2
]}

Baxter, Patricia ^{[3
]}

Hwang, Eugene ^{[4
]}

Lenzen, Alicia ^{[5
]}

MacDonald, Tobey ^{[6
]}

Pollack, Ian F. ^{[7
]}

Robison, Nathan ^{[8
]}

Vinitsky, Anna ^{[2
]}

Poussaint, Tina Young ^{[9
]}

Onar-Thomas, Arzu ^{[2
]}

Fangusaro, Jason ^{[6
]}

Dunkel, Ira J. ^{[10
]}

机构：

[1] Univ Colorado, Childrens Hosp Colorado, Anschutz Med Campus, Aurora, CO USA

[2] St Jude Childrens Res Hosp, Memphis, TN USA

[3] Baylor Coll Med, Texas Childrens Hosp, Houston, TX USA

[4] Childrens Natl Hosp, Washington, DC USA

[5] Lurie Childrens Hosp Chicago, Chicago, IL USA

[6] Aflac Canc & Blood Disorders Ctr, Chidlrens Healthcare Atlanta, Atlanta, GA USA

[7] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[8] Childrens Hosp Los Angeles, Los Angeles, CA USA

[9] Boston Childrens Hosp, Boston, MA USA

[10] Mem Sloan Kettering Canc Ctr, New York, NY USA

来源：

NEURO-ONCOLOGY | 2024年 / 26卷

关键词：

D O I：

10.1093/neuonc/noae064.159

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

TRLS-06

引用

页数：1

共 7 条

[1] PBTC-051: FIRST IN PEDIATRICS PHASE 1 STUDY OF CD40 AGONISTIC MONOCLONAL ANTIBODY APX005M IN PEDIATRIC SUBJECTS WITH RECURRENT/REFRACTORY BRAIN TUMORS
Lindsay, Holly
Onar-Thomas, Arzu
Kocak, Mehmet
Poussaint, Tina Young
Dhall, Girish
Broniscer, Alberto
Vinitsky, Anna
MacDonald, Tobey
Trifan, Ovid
Fangusaro, Jason
Dunkel, Ira
NEURO-ONCOLOGY, 2020, 22 : 304 - 304
[2] Phase 1 study to evaluate the safety and tolerability of the CD40 agonistic monoclonal antibody APX005M in subjects with solid tumors
Bendell, Johanna C.
Fakih, Marwan
Infante, Jeffrey R.
Bajor, David Lawrence
Cristea, Mihaela C.
Tremblay, Thomas
Trifan, Ovidiu C.
Vonderheide, Robert H.
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
[3] Phase 1 study to evaluate the safety and tolerability of the CD40 agonistic monoclonal antibody APX005M in subjects with solid tumors
Fakih, Marwan
Bajor, David
Mamtani, Ronac
Tremblay, Thomas
Trifan, Ovid
Vonderheide, Robert
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
[4] Phase I Trial of Lenalidomide in Pediatric Patients With Recurrent, Refractory, or Progressive Primary CNS Tumors: Pediatric Brain Tumor Consortium Study PBTC-018
Warren, Katherine E.
Goldman, Stewart
Pollack, Ian F.
Fangusaro, Jason
Schaiquevich, Paula
Stewart, Clinton F.
Wallace, Dana
Blaney, Susan M.
Packer, Roger
MacDonald, Tobey
Jakacki, Regina
Boyett, James M.
Kun, Larry E.
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (03) : 324 - 329
[5] CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study
O'Hara, Mark H.
O'Reilly, Eileen M.
Varadhachary, Gauri
Wolff, Robert A.
Wainberg, Zev A.
Ko, Andrew H.
Fisher, George
Rahma, Osama
Lyman, Jaclyn P.
Cabanski, Christopher R.
Mick, Rosemarie
Gherardini, Pier Federico
Kitch, Lacey J.
Xu, Jingying
Samuel, Theresa
Karakunnel, Joyson
Fairchild, Justin
Bucktrout, Samantha
LaVallee, Theresa M.
Selinsky, Cheryl
Till, Jacob E.
Carpenter, Erica L.
Alanio, Cecile
Byrne, Katelyn T.
Chen, Richard O.
Trifan, Ovid C.
Dugan, Ute
Horak, Christine
Hubbard-Lucey, Vanessa M.
Wherry, E. John
Ibrahim, Ramy
Vonderheide, Robert H.
LANCET ONCOLOGY, 2021, 22 (01): : 118 - 131
[6] A phase 1b/2 study of CD40 agonistic monoclonal antibody (APX005M) together with gemcitabine and nab-paclitaxel with or without nivolumab in untreated metastatic pancreatic adenocarcinoma patients
O'Hara, Mark
Mick, Rosemarie
Lyman, Jaclyn
Xu, Jingying
Hosseini, Maryam
LaVallee, Theresa
Gherardini, Pier Federico
Vance, Barbara
Trifan, Ovid
Dugan, Ute
Shalabi, Aiman
Ibrahim, Ramy
Vonderheide, Robert
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
[7] A PHASE 1 STUDY OF SAVOLITINIB IN RECURRENT, PROGRESSIVE, OR REFRACTORY MEDULLOBLASTOMA, HIGH-GRADE GLIOMA, DIFFUSE INTRINSIC PONTINE GLIOMA, AND CENTRAL NERVOUS SYSTEM (CNS) TUMORS HARBORING MET ABERRATIONS: A PEDIATRIC BRAIN TUMOR CONSORTIUM TRIAL
Salloum, Ralph
Huang, Jie
Stewart, Clinton F.
Fuller, Christine
Smolarek, Teresa
Lenzen, Alicia
Waanders, Angela J.
Baxter, Patiricia
Lindsay, Holly
Robison, Nathan
Pillay-Smiley, Natasha
Partap, Sonia
Fangusaro, Jason
Onar-Thomas, Arzu
Fouladi, Maryam
Dunkel, Ira J.
NEURO-ONCOLOGY, 2023, 25

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