Transient Neonatal Diabetes Mellitus with an Unknown Cause in a 1-Month-Old Infant: A Case Report

被引：0
作者：
Tarasiewicz, Mateusz [1 ]
Pietrzykowska, Anna [1 ]
Wlodarczyk, Julia [1 ]
Seget, Sebastian [1 ]
Gadzalska, Karolina [2 ]
Jakiel, Paulina [2 ]
Skoczylas, Sebastian [2 ]
Jarosz-Chobot, Przemyslawa [1 ]
Borowiec, Maciej [2 ]
机构：
[1] Med Univ Silesia, Dept Childrens Diabetol & Pediat, PL-40055 Katowice, Poland
[2] Med Univ Lodz, Dept Clin Genet, Lodz, Poland
来源：
HEALTHCARE | 2024年 / 12卷 / 13期
关键词：
transient neonatal diabetes mellitus; monogenic diabetes; insulin therapy; continuous glucose monitoring; next-generation sequencing; PUMP THERAPY; MANAGEMENT; MUTATIONS; INFUSION; GENE;
D O I：
10.3390/healthcare12131257
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Transient neonatal diabetes mellitus (TNDM) is a genetically heterogeneous form of neonatal diabetes characterized by hyperglycemia that remits during infancy with a tendency to recur in later life. This case report presents the history of a male infant with transient neonatal diabetes mellitus. The patient was treated with a continuous subcutaneous insulin infusion (CSII) and a continuous glucose monitoring (CGM) system until the age of 2 months, when the normoglycemia connected with a withdrawal of treatment was noted. The genetic test results excluded the majority of known mutations related to TNDM. This case report focuses on various genetic mutations and the clinical features connected with them that cause TNDM and highlights the difficulties in the diagnostic and therapeutic processes of this disease. CSII and CGM systems seem to be a safe and effective treatment option in TNDM and may be used in the therapy.
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