Increased risk of chronic fatigue syndrome following pneumonia: A population-based Cohort study

被引:1
作者
Hsu, Han-Jen [1 ]
Chang, Hsun [1 ]
Lin, Cheng-Li [2 ,3 ]
Yao, Wei-Cheng [4 ]
Hung, Chung-Lieh [8 ]
Pang, Shin -Pin [6 ]
Kuo, Chien-Feng [1 ,5 ]
Tsai, Shin-Yi [5 ,6 ,7 ,8 ,9 ,10 ]
机构
[1] MacKay Mem Hosp, Dept Internal Med, Div Infect Dis, 92,Sec 2,Zhongshan N Rd, Taipei City, Taiwan
[2] China Med Univ Hosp, Management Off Hlth Data, 2 Yude Rd, Taichung, Taiwan
[3] Taichung Vet Gen Hosp, Dept Internal Med, 1650,Sec 4,Taiwan Blvd, Taichung, Taiwan
[4] Min Sheng Gen Hosp, Dept Anesthesiol & Pain Med, 168 Jin Kuo Rd, Tao Yuan City, Taiwan
[5] Mackay Med Coll, Dept Med, 46,Sec 3,Zhongzheng Rd, New Taipei City, Taiwan
[6] Mackay Mem Hosp, Dept Lab Med, 92,Sec 2,Zhongshan N Rd, Taipei City, Taiwan
[7] Inst Biomed Sci, Mackay Med Coll, 46,Sec 3,Zhongzheng Rd, New Taipei City, Taiwan
[8] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, 615 N Wolfe St, Baltimore, MD 21205 USA
[9] Mackay Med Coll, Inst Long Term Care, 46,Sec 3,Zhongzheng Rd, New Taipei City, Taiwan
[10] 92,Sect 2,Zhongshan N Rd, Taipei City 10449, Taiwan
关键词
Chronic fatigue syndrome; Bacterial pneumonia; Viral pneumonia; Infection; National health insurance research database; SEX-DIFFERENCES; INFECTION;
D O I
10.1016/j.jiph.2024.102495
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Chronic fatigue syndrome (CFS) has been linked to several conditions, including infections, immune system changes, or emotional stress. Our study aimed to assess the risk of CFS after a pneumonia diagnosis using data from National Health Insurance Research Database of Taiwan. Methods: In this nested case-control study, we identified 2,000,000 adult patients from a nationwide population-based health insurance claims database spanning from January 1, 2000, to December 31, 2017. Each case diagnosed with a pathogenic infection was matched with a corresponding control using propensity scores. We excluded individuals under 20 years of age, those with a history of pathogenic infections before the index date, or those with more than one potential pathogen. To estimate hazard ratios (HR) and the adjusted hazard ratio (aHR) with their respective 95 % confidence intervals (CI), we applied univariable and multivariable Cox proportional hazard models. The multivariable analysis incorporated adjustments for age, sex, and comorbidity-related confounders. Results: The relationship between infection and the subsequent risk of CFS was assessed using Cox proportional hazards regression analysis. The incidence density rates were 6.13 and 8.70 per 1000 person-years among the non-pulmonary infection and pulmonary infection populations, respectively (adjusted hazard ratio [HR] = 1.4, 95 % confidence interval [CI] 1.32-1.5). Patients infected with Pseudomonas, Klebsiella pneumoniae, Haemophilus influenzae, Streptococcus pneumoniae, and influenza virus exhibited a significantly higher risk of CFS than those without these pathogens (p < 0.05). Additionally, patients with pneumonia had a significantly increased risk of thromboembolism compare with control group (p < 0.05). (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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页数:9
相关论文
共 36 条
  • [1] Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety, and chronic fatigue syndrome-like symptoms due to COVID-19: A nomothetic network approach
    Al-Jassas, Hawraa Kadhem
    Al-Hakeim, Hussein Kadhem
    Maes, Michael
    [J]. JOURNAL OF AFFECTIVE DISORDERS, 2022, 297 : 233 - 245
  • [2] Lung-brain axis
    Bajinka, Ousman
    Simbilyabo, Lucette
    Tan, Yurong
    Jabang, John
    Saleem, Shakeel Ahmed
    [J]. CRITICAL REVIEWS IN MICROBIOLOGY, 2022, 48 (03) : 257 - 269
  • [3] Review of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: an evidence-based approach to diagnosis and management by clinicians
    Bested, Alison C.
    Marshall, Lynn M.
    [J]. REVIEWS ON ENVIRONMENTAL HEALTH, 2015, 30 (04) : 223 - 249
  • [4] Ceribelli Angela, 2019, Mediterr J Rheumatol, V30, P162, DOI 10.31138/mjr.30.3.162
  • [5] Presence of depression and anxiety with distinct patterns of pharmacological treatments before the diagnosis of chronic fatigue syndrome: a population-based study in Taiwan
    Chen, Chi
    Yip, Hei-Tung
    Leong, Kam-Hang
    Yao, Wei-Cheng
    Hung, Chung-Lieh
    Su, Ching-Huang
    Kuo, Chien-Feng
    Tsai, Shin-Yi
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2023, 21 (01)
  • [6] The Economic Impacts of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in an Australian Cohort
    Close, Shara
    Marshall-Gradisnik, Sonya
    Byrnes, Joshua
    Smith, Peter
    Nghiem, Son
    Staines, Don
    [J]. FRONTIERS IN PUBLIC HEALTH, 2020, 8
  • [7] Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review
    Cortes Rivera, Mateo
    Mastronardi, Claudio
    Silva-Aldana, Claudia T.
    Arcos-Burgos, Mauricio
    Lidbury, Brett A.
    [J]. DIAGNOSTICS, 2019, 9 (03)
  • [8] Cullinan John, 2020, HRB Open Res, V3, P88, DOI 10.12688/hrbopenres.13181.1
  • [9] The estrogen metabolite 17β-dihydroequilenin counteracts interleukin-1α induced expression of inflammatory mediators in human endothelial cells in vitro via NF-κB pathway
    Demyanets, S
    Pfaffenberger, S
    Kaun, C
    Rega, G
    Speidl, WS
    Kastl, SP
    Weiss, TW
    Hohensinner, PJ
    Dietrich, W
    Tschugguel, W
    Bochkov, VN
    Awad, EM
    Maurer, G
    Huber, K
    Wojta, J
    [J]. THROMBOSIS AND HAEMOSTASIS, 2006, 95 (01) : 107 - 116
  • [10] Association of mitochondrial dysfunction and fatigue: A review of the literature
    Filler, Kristin
    Lyon, Debra
    Bennett, James
    McCain, Nancy
    Elswick, Ronald
    Lukkahatai, Nada
    Saligan, Leorey N.
    [J]. BBA CLINICAL, 2014, 1 : 12 - 23