Study of activation cross sections of double neutron capture reaction on 193Ir for the reactor production route of radiotherapeutic 195mPt

被引：0
作者：
Madumarov, Alexander S. [1 ]
Aksenov, Nikolay, V [1 ]
Bozhikov, Gospodin A. [1 ]
Astakhov, Andrey A. [1 ]
Albin, Yury, V [1 ]
Bulavin, Maksim, V [2 ]
Shabalin, Evgeny P. [2 ]
Dmitriev, Sergey N. [1 ]
机构：
[1] Joint Inst Nucl Res, Flerov Lab Nucl React, Joliot Curie 6, Dubna 141980, Russia
[2] Joint Inst Nucl Res, Frank Lab Neutron Phys, Joliot Curie 6, Dubna 141980, Russia
来源：
NUCLEAR MEDICINE AND BIOLOGY | 2024年 / 134卷
关键词：
Theranostics; Auger electron; Radionuclide production; Extraction chromatography; Neutron cross sections; THERAPY; FLUX;
D O I：
10.1016/j.nucmedbio.2024.108928
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The radiotherapeutic Pt-195m is among the most effective Auger electron emitters of the currently studied radionuclides that have a potential theranostic application in nuclear medicine. Production of Pt-195m through double neuron capture of enriched Ir-193 followed by beta(-)-decay to the radioisotope of interest carried out at the research reactor IBR-2 is described. Because of the high radiation background, radiochemical purification procedure of (195)mPt from bulk of iridium was needed to be developed and is detailed here as well. For the first time, cross section and resonance integral for the reaction Ir-194(n,gamma)(195)mIr were determined. Resonance neutrons contribution was established to exceed that of thermal neutrons, and resonance integral for the reaction Ir-194 (n,gamma)(195)mIr is calculated to be 2900 b. Specific activity of (195)mPt was estimated to reach a value of 38.7 GBq/(g Pt) at IBR-2 by the end of bombardment (EOB).
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页数：7
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