Sensitive and specific assay for the serological diagnosis of anti-p200 pemphigoid based on the recombinant laminin β4 subunit

被引：5

作者：

Goletz, Stephanie ^{[1
]}

Probst, Christian ^{[3
]}

Komorowski, Lars ^{[3
]}

Radzimski, Christiane ^{[3
]}

Mindorf, Swantje ^{[3
]}

Holtsche, Maike M. ^{[1
,2
]}

Pigors, Manuela ^{[1
]}

van Beek, Nina ^{[1
,2
]}

Zillikens, Detlef ^{[2
]}

Schlumberger, Wolfgang ^{[3
]}

Schmidt, Enno ^{[1
,2
]}

机构：

[1] Univ Lubeck, Lubeck Inst Expt Dermatol, Lubeck, Germany

[2] Univ Lubeck, Dept Dermatol, Lubeck, Germany

[3] EUROIMMUN AG, Inst Expt Immunol, Lubeck, Germany

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2024年 / 191卷 / 01期

关键词：

D O I：

10.1093/bjd/ljae136

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Anti-p200 pemphigoid is an autoimmune blistering disease that often resembles other pemphigoid disorders. We developed a test for the detection of autoantibodies against laminin beta 4, an autoantigen in anti-p200 pemphigoid, to facilitate its diagnosis. The test demonstrated excellent sensitivity and specificity, making it a valuable tool for diagnosing this disease and distinguishing it from similar skin disorders.

引用

页码：140 / 141

页数：2

共 8 条

[1] Anti-laminin gamma-1 pemphigoid [J].

Dainichi, Teruki ;

Kurono, Sadamu ;

Ohyama, Bungo ;

Ishii, Norito ;

Sanzen, Noriko ;

Hayashi, Maria ;

Shimono, Chisei ;

Taniguchi, Yukimasa ;

Koga, Hiroshi ;

Karashima, Tadashi ;

Yasumoto, Shinichiro ;

Zillikens, Detlef ;

Sekiguchi, Kiyotoshi ;

Hashimoto, Takashi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (08) :2800-2805

[2] Laminin β4 is a constituent of the cutaneous basement membrane zone and additional autoantigen of anti-p200 pemphigoid [J].

Goletz, Stephanie ;

Pigors, Manuela ;

Lari, Tina Rastegar ;

Hammers, Christoph M. ;

Wang, Yao ;

Emtenani, Shirin ;

Aumailley, Monique ;

Holtsche, Maike M. ;

Stang, Felix H. ;

Weyers, Imke ;

Koenig, Inke R. ;

Has, Cristina ;

Radzimski, Christiane ;

Komorowski, Lars ;

Zillikens, Detlef ;

Schmidt, Enno .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2024, 90 (04) :790-797

[3] Development of a simple enzyme-linked immunosorbent assay for the detection of autoantibodies in anti-p200 pemphigoid [J].

Groth, S. ;

Recke, A. ;

Vafia, K. ;

Ludwig, R. J. ;

Hashimoto, T. ;

Zillikens, D. ;

Schmidt, E. .

BRITISH JOURNAL OF DERMATOLOGY, 2011, 164 (01) :76-82

[4] Anti-p200 Pemphigoid: A Systematic Review [J].

Kridin, Khalaf ;

Ahmed, A. Razzaque .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[5] Serologic characterization of anti-p200 pemphigoid: Epitope spreading as a common phenomenon [J].

Puri, Pranav ;

Baliga, Sujith ;

Pittelkow, Mark R. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2021, 84 (04) :1155-1157

[6] Diagnosis of anti-laminin γ-1 pemphigoid by immunoblot analysis [J].

Solimani, F. ;

Pollmann, R. ;

Ishii, N. ;

Eming, R. ;

Hashimoto, T. ;

Schmidt, T. ;

Hertl, M. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2019, 33 (04) :735-741

[7] Incidence of pemphigoid diseases in Northern Germany in 2016-first data from the Schleswig-Holstein Registry of Autoimmune Bullous Diseases [J].

van Beek, N. ;

Weidinger, A. ;

Schneider, S. W. ;

Kleinheinz, A. ;

Glaeser, R. ;

Holtsche, M. M. ;

von Georg, A. ;

Hammers, C. M. ;

Huebner, F. ;

Lima, A-L ;

Gola, D. ;

Sadik, C. D. ;

Zillikens, D. ;

Katalinic, A. ;

Schmidt, E. ;

Koenig, I. R. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2021, 35 (05) :1197-1202

[8] A novel subepidermal blistering disease with autoantibodies to a 200-kDa antigen of the basement membrane zone (vol 106, pg 465, 1996) [J].

Zillikens, D ;

Kawahara, Y ;

Ishiko, A ;

Shimizu, H ;

Mayer, J ;

Rank, CV ;

Liu, Z ;

Giudice, GJ ;

Tran, HH ;

Marinkvch, MP ;

Brocker, EB ;

Hashimoto, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (06) :1332-1338

← 1 →