The mitochondrial multi-omic response to exercise training across rat tissues

被引：36

作者：

Amar, David ^{[1
,15
]}

Gay, Nicole R. ^{[1
]}

Jimenez-Morales, David ^{[1
]}

Beltran, Pierre M. Jean ^{[2
]}

Ramaker, Megan E. ^{[3
]}

Raja, Archana Natarajan ^{[1
]}

Zhao, Bingqing ^{[1
]}

Sun, Yifei ^{[4
]}

Marwaha, Shruti ^{[1
]}

Gaul, David A. ^{[5
]}

Hershman, Steven G. ^{[1
]}

Ferrasse, Alexis ^{[1
]}

Xia, Ashley ^{[6
]}

Lanza, Ian ^{[7
]}

Fernandez, Facundo M. ^{[5
]}

Montgomery, Stephen B. ^{[1
]}

Hevener, Andrea L. ^{[8
]}

Ashley, Euan A. ^{[1
]}

Walsh, Martin J. ^{[4
]}

Sparks, Lauren M. ^{[9
]}

Burant, Charles F. ^{[10
]}

Rector, R. Scott ^{[11
]}

Thyfault, John ^{[12
]}

Wheeler, Matthew T. ^{[1
]}

Goodpaster, Bret H. ^{[9
]}

Coen, Paul M. ^{[9
]}

Schenk, Simon ^{[13
]}

Bodine, Sue C. ^{[14
]}

Lindholm, Malene E. ^{[1
]}

机构：

[1] Stanford Univ, Stanford, CA 94305 USA

[2] Broad Inst, Boston, MA USA

[3] Duke Univ, Durham, NC USA

[4] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[5] Georgia Inst Technol, Atlanta, GA USA

[6] NIH, Bethesda, MD USA

[7] Mayo Clin, Rochester, MN USA

[8] Univ Calif Los Angeles, Los Angeles, CA USA

[9] AdventHealth, Translat Res Inst, Orlando, FL USA

[10] Univ Michigan, Ann Arbor, MI USA

[11] Univ Missouri, Columbia, MO USA

[12] Univ Kansas, Med Ctr, Kansas City, KS USA

[13] Univ Calif San Diego, La Jolla, CA USA

[14] Oklahoma Med Res Fdn, Oklahoma City, OK USA

[15] Insitro, San Francisco, CA USA

来源：

CELL METABOLISM | 2024年 / 36卷 / 06期

基金：

美国国家卫生研究院;

关键词：

BROWN ADIPOSE-TISSUE; DNA COPY NUMBER; SKELETAL-MUSCLE; BIOCHEMICAL ADAPTATIONS; REPLICABILITY ANALYSIS; PROTEIN ACETYLATION; ENDURANCE EXERCISE; SIRT3; DEACETYLATES; MASS-SPECTROMETRY; PHYSICAL-ACTIVITY;

D O I：

10.1016/j.cmet.2023.12.021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondria have diverse functions critical to whole -body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium mapped the temporal, multi-omic changes in mitochondrial alytes across 19 tissues in male and female rats trained for 1, 2, 4, or 8 weeks. Training elicited substantial changes in the adrenal gland, brown adipose, colon, heart, and skeletal muscle. The colon showed non-linear response dynamics, whereas mitochondrial pathways were downregulated in brown adipose and adrenal tissues. Protein acetylation increased in the liver, with a shift in lipid metabolism, whereas oxidative proteins increased in striated muscles. Exercise-upregulated networks were downregulated in human diabetes and cirrhosis. Knockdown of the central network protein 17-beta-hydroxysteroid dehydrogenase (HSD17B10) elevated oxygen consumption, indicative of metabolic stress. We provide a multi-omic, multi tissue, temporal atlas of the mitochondrial response to exercise training and identify candidates linked mitochondrial dysfunction.

引用

页码：1411 / 1429.e10

页数：30

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