Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

被引：10

作者：

Guo, Jinhong ^{[1
]}

Yan, Wenjie ^{[1
]}

Duan, Hao ^{[1
]}

Wang, Diandian ^{[1
]}

Zhou, Yaxi ^{[1
]}

Feng, Duo ^{[2
]}

Zheng, Yue ^{[3
]}

Zhou, Shiqi ^{[1
]}

Liu, Gaigai ^{[1
]}

Qin, Xia ^{[4
]}

机构：

[1] Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, Beijing 100023, Peoples R China

[2] Minist Agr & Rural Affairs, Inst Food & Nutr Dev, Beijing 100081, Peoples R China

[3] Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Peoples R China

[4] Beijing Union Univ, Grad Dept, Beijing 100101, Peoples R China

来源：

NUTRIENTS | 2024年 / 16卷 / 11期

关键词：

natural products; liver cancer; therapeutic drugs; mechanisms of action; HEPATOCELLULAR-CARCINOMA CELLS; ANTITUMOR-ACTIVITY; STRUCTURAL-CHARACTERIZATION; PI3K/AKT/MTOR PATHWAY; DOWN-REGULATION; APOPTOSIS; POLYSACCHARIDE; SORAFENIB; NANOPARTICLES; PROLIFERATION;

D O I：

10.3390/nu16111642

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting a growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, and minimal side effects. This paper begins by reviewing existing treatment methods and drugs for liver cancer. It then summarizes the therapeutic effects of NPs sourced from various origins on liver cancer. Finally, we analyze the potential mechanisms of NPs in treating liver cancer, including inhibition of angiogenesis, migration, and invasion; regulation of the cell cycle; induction of apoptosis, autophagy, pyroptosis, and ferroptosis; influence on tumor metabolism; immune regulation; regulation of intestinal function; and regulation of key signaling pathways. This systematic review aims to provide a comprehensive overview of NPs research in liver cancer treatment, offering a foundation for further development and application in pharmaceuticals and functional foods.

引用

页数：36

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