Language and communication functioning in children and adolescents with agenesis of the corpus callosum

被引：0

作者：

Moser, Charlene ^{[1
]}

Spencer-Smith, Megan M. ^{[2
,3
]}

Anderson, Peter J. ^{[2
]}

McIlroy, Alissandra ^{[3
,4
]}

Wood, Amanda G. ^{[3
,5
,6
]}

Leventer, Richard J. ^{[3
,7
,8
]}

Anderson, Vicki A. ^{[3
,7
,9
]}

Siffredi, Vanessa ^{[3
,10
,11
,12
,13
]}

机构：

[1] Lausanne Univ Hosp, Lausanne, Switzerland

[2] Monash Univ, Sch Psychol Sci, Melbourne, Australia

[3] Murdoch Childrens Res Inst, Clin Sci, Parkville, Vic, Australia

[4] Monash Univ, Cent Clin Sch, Dept Neurosci, Melbourne, Australia

[5] Deakin Univ, Sch Psychol, Burwood, Vic, Australia

[6] Aston Univ, Aston Inst Hlth & Neurodev, Birmingham, England

[7] Univ Melbourne, Dept Paediat, Melbourne, Australia

[8] Royal Childrens Hosp, Dept Neurol, Melbourne, Australia

[9] Royal Childrens Hosp, Melbourne, Australia

[10] Geneva Univ Hosp, Dept Paediat Gynaecol & Obstet, Div Dev & Growth, Geneva Campus Biotech,Chemin Mines 9, CH-1209 Geneva, Switzerland

[11] Univ Geneva, Geneva Campus Biotech,Chemin Mines 9, CH-1209 Geneva, Switzerland

[12] Lausanne Univ Hosp, Dept Radiol, Lausanne, Switzerland

[13] Univ Lausanne, Lausanne, Switzerland

来源：

BRAIN AND LANGUAGE | 2024年 / 255卷

基金：

英国医学研究理事会;

关键词：

Agenesis of the corpus callosum; Corpus callosum; Language and communication; Children and adolescents; Developmental neuropsychology; DIAGNOSED ISOLATED AGENESIS; NEUROPSYCHOLOGICAL PROFILE; SOCIOECONOMIC-STATUS; FOLLOW-UP; LATERALIZATION; COMPREHENSION; CONNECTIVITY; DEFICITS; AGE; INDIVIDUALS;

D O I：

10.1016/j.bandl.2024.105448

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

The corpus callosum, the largest white matter inter-hemispheric pathway, is involved in language and communication. In a cohort of 15 children and adolescents (8-15 years) with developmental absence of the corpus callosum (AgCC), this study aimed to describe language and everyday communication functioning, and explored the role of anatomical factors, social risk, and non-verbal IQ in these outcomes. Standardised measures of language and everyday communication functioning, intellectual ability and social risk were used. AgCC classification and anterior commissure volume, a potential alternative pathway, were extracted from T1weighted images. Participants with AgCC showed reduced receptive and expressive language compared with test norms, and high rates of language and communication impairments. Complete AgCC, higher social risk and lower non-verbal IQ were associated with communication difficulties. Anterior commissure volume was not associated with language and communication. Recognising heterogeneity in language and communication functioning enhances our understanding and suggests specific focuses for potential interventions.

引用

页数：9