Enantioselective separation techniques in forensic analysis and clinical toxicology

被引:2
作者
Busardo, Francesco Paolo [1 ]
Tini, Anastasio [1 ]
Lo Faro, Alfredo Fabrizio [1 ]
Basile, Giuseppe [2 ]
Farkas, Tivadar [3 ]
Chankvetadze, Bezhan [3 ]
机构
[1] Univ Politecn Marche Ancona, Dept Excellence Biomed Sci & Publ Hlth, Via Tronto 10-A, I-60126 Ancona, Italy
[2] Univ Politecn Marche Ancona, Sch Legal Med, Via Tronto 10-A, Ancona, Italy
[3] Tbilisi State Univ, Inst Phys & Analyt Chem, Sch Exact & Nat Sci, Tbilisi 0179, Georgia
基金
美国国家科学基金会;
关键词
Clinical toxicology; Enantioselective analysis; Forensic analysis; TANDEM MASS-SPECTROMETRY; SUPERCRITICAL-FLUID CHROMATOGRAPHY; CHIRAL CAPILLARY-ELECTROPHORESIS; AMPHETAMINE-TYPE STIMULANTS; HIGHLY SULFATED CYCLODEXTRIN; NATIVE BETA-CYCLODEXTRIN; AMINO-ACID ENANTIOMERS; GC-EI-MS; LIQUID-CHROMATOGRAPHY; HUMAN URINE;
D O I
10.1016/j.trac.2024.117733
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Enantioselective analysis is more demanding compared to non-enantioselective one from the viewpoint of time, effort and resources. At the same time if correctly designed it may bring additional information and value to forensic scientists and clinical toxicologists. This short overview describes difficulties versus the added value of enantioselective separations in forensic analysis and clinical toxicology. The specific requirements of enantioselective analytical methods as applied to forensic analysis are summarized in this review and the various separation techniques that such methods are based on are compared to each other from the perspective of forensic analysis. In the final part, the current challenges in this field are shortly reviewed and future trends are highlighted.
引用
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页数:23
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