Atopic Dermatitis Itch: Scratching for an Explanation

被引：11

作者：

Soares, Georgia Biazus ^{[1
]}

Hashimoto, Takashi ^{[2
]}

Yosipovitch, Gil ^{[1
,3
]}

机构：

[1] Univ Miami, Miami Itch Ctr, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miller Sch Med, Miami, FL USA

[2] Natl Def Med Coll, Dept Dermatol, Tokorozawa, Japan

[3] Univ Miami, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miller Sch Med, 5555 Ponce Leon, Coral Gables, FL 33146 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2024年 / 144卷 / 05期

基金：

日本学术振兴会;

关键词：

Atopic Dermatitis; Itch; Pruritus; PROTEINASE-ACTIVATED RECEPTOR-2; GASTRIN-RELEASING-PEPTIDE; HISTAMINE-INDUCED ITCH; SUBSTANCE-P; MAST-CELL; COUPLED RECEPTORS; LESIONAL SKIN; MEDIATES ITCH; SERUM-LEVELS; KALLIKREIN;

D O I：

10.1016/j.jid.2023.10.048

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Chronic pruritus is a cardinal symptom of atopic dermatitis (AD). The mechanisms underlying atopic itch involve intricate crosstalk among skin, immune components, and neural components. In this review, we explore these mechanisms, focusing on key players and interactions that induce and exacerbate itch. We discuss the similarities and differences between pruritus and pain in patients with AD as well as the relationship between pruritus and factors such as sweat and the skin microbiome. Furthermore, we explore novel targets that could provide significant itch relief in these patients as well as exciting future research directions to better understand atopic pruritus in darker skin types.

引用

收藏

页码：978 / 988

页数：11

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