The efficacy of low frequency repetitive transcial magnetic stimulation for treating auditory verbal hallucinations in schizophrenia: Insights from functional gradient analyses

被引：1

作者：

Xie, Yuanjun ^{[1
,2
]}

Li, Chenxi ^{[1
]}

Guan, Muzhen ^{[3
]}

Zhang, Tian ^{[1
]}

Ma, Chaozong ^{[1
]}

Wang, Zhongheng ^{[4
]}

Ma, Zhujing ^{[1
]}

Wang, Huaning ^{[4
]}

Fang, Peng ^{[1
,5
,6
]}

机构：

[1] Fourth Mil Med Univ, Mil Med Psychol Sch, Xian, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian, Peoples R China

[3] Xian Med Coll, Dept Mental Hlth, Xian, Peoples R China

[4] Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian, Peoples R China

[5] Shaanxi Prov Key Lab Bioelectromagnet Detect & Int, Xian, Peoples R China

[6] Fourth Mil Med Univ, Mil Med Innovat Ctr, Xian, Peoples R China

来源：

HELIYON | 2024年 / 10卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Auditory verbal hallucinations; Schizophrenia; Repetitive transcranial magnetic stimulation; Functional gradient; Brain connectivity patterns; DEFAULT-MODE NETWORK; PRIMARY MOTOR CORTEX; EXCITATORY POSTSYNAPSES; NEURONAL-ACTIVITY; SOCIAL COGNITION; WORKING-MEMORY; FRONTAL-CORTEX; BRAIN NETWORKS; CONNECTIVITY; EMOTION;

D O I：

10.1016/j.heliyon.2024.e30194

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Auditory Verbal Hallucinations (AVH) constitute a prominent feature of schizophrenia. Although low-frequency repetitive transcranial magnetic stimulation (rTMS) has demonstrated therapeutic benefits in ameliorating AVH, the underlying mechanisms of its efficacy necessitate further elucidation. Objective: This study investigated the cortical gradient characteristics and their associations with clinical responses in schizophrenia patients with AVH, mediated through 1 Hz rTMS targeting the left temporoparietal junction. Method: Functional gradient metrics were employed to examine the hierarchy patterns of cortical organization, capturing whole-brain functional connectivity profiles in patients and controls. Results: The 1 Hz rTMS treatment effectively ameliorated the positive symptoms in patients, specifically targeting AVH. Initial evaluations revealed expanded global gradient distribution patterns and specific principal gradient variations in certain brain regions in patients at baseline compared to a control cohort. Following treatment, these divergent global and local patterns showed signs of normalizing. Furthermore, there was observed a closer alignment in betweennetwork dispersion among various networks after treatment, including the somatomotor, attention, and limbic networks, indicating a potential harmonization of brain functionality. Conclusion: Low-frequency rTMS induces alternations in principal functional gradient patterns, may serve as imaging markers to elucidate the mechanisms underpinning the therapeutic efficacy of rTMS on AVH in schizophrenia.

引用

页数：12

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