The Impact of Prophylactic Post-Chemotherapy G-CSF on the Relapse Rates in Patients with Acute Myeloid Leukemia: A Meta-Analysis

被引：4

作者：

Bordbar, Mohammadreza ^{[1
]}

Hosseini-Bensenjan, Mahnaz ^{[1
]}

Sayadi, Mehrab ^{[2
]}

Zekavat, Omidreza ^{[1
]}

Bordbar, Shayan ^{[3
]}

Nozari, Farnoosh ^{[1
]}

Haghpanah, Sezaneh ^{[1
]}

机构：

[1] Shiraz Univ Med Sci, Hematol Res Ctr, Shiraz, Iran

[2] Shiraz Univ Med Sci, Cardiovasc Res Ctr, Shiraz, Iran

[3] Shiraz Univ Med Sci, Student Res Ctr, Shiraz, Iran

来源：

CANCER INVESTIGATION | 2024年 / 42卷 / 06期

关键词：

Acute myeloid leukemia; granulocyte colony-stimulating factor; relapse; survival; meta-analysis; COLONY-STIMULATING FACTOR; HEMATOPOIETIC GROWTH-FACTORS; ACUTE MYELOGENOUS LEUKEMIA; PLACEBO-CONTROLLED TRIAL; INDUCTION CHEMOTHERAPY; FEBRILE NEUTROPENIA; RANDOMIZED-TRIAL; ELDERLY-PATIENTS; DOUBLE-BLIND; CELL-CYCLE;

D O I：

10.1080/07357907.2024.2352454

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This meta-analysis evaluated the impact of prophylactic post-chemotherapy granulocyte colony-stimulating factor (G-CSF) in patients with acute myeloid leukemia (AML). Overall, the relapse rate, overall survival, event-free survival, and mortality rate were similar in G-CSF (+) compared to G-CSF (-) patients. However, the relative risk (RR) of relapse was higher in children and in secondary AML patients who were treated with G-CSF compared to the G-CSF (-) group [RR, 95% confidence interval: 1.26, 1.04-1.52, and 1.12 (1.02-1.24)]. Treatment with post-chemotherapy G-CSF should be prescribed with caution in pediatric patients with AML and secondary AML as possibly increasing the relapse risk.

引用

页码：452 / 468

页数：17

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