Ginsenosides Decrease β-Amyloid Production via Potentiating Capacitative Calcium Entry
被引:2
作者:
Cho, Yoon Young
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机构:
Sungkyunkwan Univ, Sch Med, Dept Physiol, Suwon 16419, South KoreaSungkyunkwan Univ, Sch Med, Dept Physiol, Suwon 16419, South Korea
Cho, Yoon Young
[1
]
Park, Jeong Hill
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机构:
Seoul Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Seoul 08826, South KoreaSungkyunkwan Univ, Sch Med, Dept Physiol, Suwon 16419, South Korea
Park, Jeong Hill
[2
]
Lee, Jung Hee
论文数: 0引用数: 0
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机构:
Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiol, Seoul 06351, South KoreaSungkyunkwan Univ, Sch Med, Dept Physiol, Suwon 16419, South Korea
Lee, Jung Hee
[3
]
论文数: 引用数:
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机构:
Chung, Sungkwon
[1
]
机构:
[1] Sungkyunkwan Univ, Sch Med, Dept Physiol, Suwon 16419, South Korea
[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Seoul 08826, South Korea
[3] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiol, Seoul 06351, South Korea
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder characterized by extracellular amyloid plaques composed of amyloid beta-peptide (A beta). Studies have indicated that Ca2+ dysregulation is involved in AD pathology. It is reported that decreased capacitative Ca2+ entry (CCE), a refilling mechanism of intracellular Ca2+, resulting in increased A beta production. In contrast, constitutive activation of CCE could decrease A beta production. Panax ginseng Meyer is known to enhance memory and cognitive functions in healthy human subjects. We have previously reported that some ginsenosides decrease A beta levels in cultured primary neurons and AD mouse model brains. However, mechanisms involved in the A beta-lowering effect of ginsenosides remain unclear. In this study, we investigated the relationship between CCE and A beta production by examining the effects of various ginsenosides on CCE levels. A beta-lowering ginsenosides such as Rk1, Rg5, and Rg3 potentiated CCE. In contrast, ginsenosides without A beta-lowering effects (Re and Rb2) failed to potentiate CCE. The potentiating effect of ginsenosides on CCE was inhibited by the presence of 2-aminoethoxydiphenyl borate (2APB), an inhibitor of CCE. 2APB alone increased A beta 42 production. Furthermore, the presence of 2APB prevented the effects of ginsenosides on A beta 42 production. Our results indicate that ginsenosides decrease A beta production via potentiating CCE levels, confirming a close relationship between CCE levels and A beta production. Since CCE levels are closely related to A beta production, modulating CCE could be a novel target for AD therapeutics.
机构:
Massachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
Harvard Med Sch, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
Calvo-Rodriguez, Maria
;
Kharitonova, Elizabeth K.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
Harvard Med Sch, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
Kharitonova, Elizabeth K.
;
Bacskai, Brian J.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
Harvard Med Sch, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Cao, Guoqiong
;
Su, Ping
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Su, Ping
;
Zhang, Shuai
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机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Zhang, Shuai
;
Guo, Limin
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机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Guo, Limin
;
Zhang, Haijing
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Zhang, Haijing
;
Liang, Yuexia
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Liang, Yuexia
;
Qin, Chunxia
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Qin, Chunxia
;
Zhang, Wensheng
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R China
Natl & Local United Engn Res Ctr Sanqi Resources, Kunming 650000, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
机构:
Harvard Univ, Childrens Hosp, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USAHarvard Univ, Childrens Hosp, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA
机构:
Massachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
Harvard Med Sch, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
Calvo-Rodriguez, Maria
;
Kharitonova, Elizabeth K.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
Harvard Med Sch, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
Kharitonova, Elizabeth K.
;
Bacskai, Brian J.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
Harvard Med Sch, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Neurol, Alzheimer Res Unit, Charlestown, MA 02129 USA
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Cao, Guoqiong
;
Su, Ping
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Su, Ping
;
Zhang, Shuai
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Zhang, Shuai
;
Guo, Limin
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Guo, Limin
;
Zhang, Haijing
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Zhang, Haijing
;
Liang, Yuexia
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Liang, Yuexia
;
Qin, Chunxia
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Qin, Chunxia
;
Zhang, Wensheng
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
Beijing Normal Univ, Engn Res Ctr Nat Med, Minist Educ, Beijing 100088, Peoples R China
Beijing Normal Univ, Coll Resources Sci Technol, Beijing 100875, Peoples R China
Natl & Local United Engn Res Ctr Sanqi Resources, Kunming 650000, Peoples R ChinaBeijing Normal Univ, Beijing Area Major Lab Protect & Utilizat Tradit, Beijing 100088, Peoples R China
机构:
Harvard Univ, Childrens Hosp, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USAHarvard Univ, Childrens Hosp, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA