The role of dyslipidemia in diabetic retinopathy

被引：64

作者：

Hammer, Sandra S. ^{[1
]}

Busik, Julia V. ^{[1
]}

机构：

[1] Michigan State Univ, Dept Physiol, 567 Wilson Rd, E Lansing, MI 48824 USA

来源：

VISION RESEARCH | 2017年 / 139卷

关键词：

Dyslipidemia; Diabetic retinopathy; Inflammation; Cholesterol metabolism; Fatty acids; ASM; miR-15a; Liver X receptor; Bone marrow; RETINAL ENDOTHELIAL-CELLS; LIVER-X-RECEPTORS; ACID SPHINGOMYELINASE; FATTY-ACIDS; DOCOSAHEXAENOIC ACID; LIPID-METABOLISM; MOUSE RETINA; CHOLESTEROL HOMEOSTASIS; LIPOPROTEIN METABOLISM; VASCULAR INFLAMMATION;

D O I：

10.1016/j.visres.2017.04.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Diabetic retinopathy (DR) affects over 93 million people worldwide and is the number one cause of blindness among working age adults. These indicators coupled with the projected rise of patients diagnosed with diabetes, makes DR a serious and prevalent vision threating disease. Data from recent clinical trials demonstrate that in addition to the well accepted role of hyperglycemia, dyslipidemia is an important, but often overlooked factor in the development of DR. The central aim of this review article is to showcase the critical role of dyslipidemia in DR progression as well as highlight novel therapeutic solutions that take advantage of the vital roles lipid metabolism plays in DR progression. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：228 / 236

页数：9

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