Therapeutic effect of tyndallized Lactobacillus rhamnosus IDCC 3201 on atopic dermatitis mediated by down-regulation of immunoglobulin E in NC/Nga mice

被引：39
作者：
Lee, Seung-Hun [1 ,2 ]
Yoon, Jong-Min [1 ]
Kim, Young-Hoo [1 ]
Jeong, Dong-Gu [1 ]
Park, Soobong [1 ]
Kang, Dae-Jung [1 ]
机构：
[1] Ildong Pharmaceut, Res Labs, 20,Samsung 1 Ro 1 Gil, Hwaseong 18449, South Korea
[2] Konkuk Univ, Dept Biotechnol & Bioengn, 120 Neungdong Ro, Seoul 05029, South Korea
来源：
MICROBIOLOGY AND IMMUNOLOGY | 2016年 / 60卷 / 07期
关键词：
atopic dermatitis; immunoglobulin E; Lactobacillus rhamnosus; tyndallization; PREVENTS DEVELOPMENT; FERMENTED MILK; SKIN-LESIONS; PROBIOTICS; CHILDREN; GUT; STRAINS; HEALTH; IGE;
D O I：
10.1111/1348-0421.12390
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The therapeutic effect of oral administration of Lactobacillus rhamnosus IDCC 3201 tyndallizate (RHT3201) on atopic dermatitis (AD)-like skin lesions in NC/Nga mice were investigated. After induction of dermatitis in NC/Nga mice with house-dust mite extract, each group was fed RHT3201 with 1x10(8), 1x10(9), or 1x10(10) cells orally once a day for 8 weeks. Dermatitis scores and frequency of scratching were improved by oral feeding with RHT3201. In contrast to the control group, RHT3201-fed mice showed significantly down-regulated mast cell numbers and serum immunoglobulin E (IgE) concentrations had significantly less IL4 in their axillary lymph node cells. The therapeutic effect of RHT3201 was found to be dose-dependent. These findings indicate that RHT3201 has potential for treating AD.
引用
收藏
页码：468 / 476
页数：9
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