Immune-Escape Mutations Are Prevalent among Patients with a Coexistence of HBsAg and Anti-HBs in a Tertiary Liver Center in the United States

被引:3
作者
Ali, Mukarram Jamat [1 ,2 ]
Shah, Pir Ahmed [1 ]
Rehman, Khalil Ur [1 ]
Kaur, Satinder [1 ]
Holzmayer, Vera [3 ]
Cloherty, Gavin A. [3 ]
Kuhns, Mary C. [3 ]
Lau, Daryl T. Y. [1 ]
机构
[1] Harvard Med Sch, Liver Ctr, Beth Israel Deaconess Med Ctr, Dept Med,Div Gastroenterol & Hepatol, Boston, MA 02215 USA
[2] Howard Univ, Howard Univ Hosp, Coll Med, Washington, DC 20060 USA
[3] Abbott Labs, Abbott Diagnost Div, Abbott Pk, IL 60064 USA
来源
VIRUSES-BASEL | 2024年 / 16卷 / 05期
关键词
HBsAg mutation; vaccine-escape mutant; S gene; 'alpha' determinant region; HEPATITIS-B-VIRUS; SURFACE-ANTIGEN; PRE-S; VIRION SECRETION; WILD-TYPE; CARRIERS; GENE; VARIANTS; ANTIBODIES; INFECTION;
D O I
10.3390/v16050713
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The concurrent seropositivity of HBsAg and anti-HBs has been described among patients with chronic hepatitis B (CHB), but its prevalence is variable. HBV S-gene mutations can affect the antigenicity of HBsAg. Patients with mutations in the 'alpha' determinant region of the S gene can develop severe HBV reactivation under immunosuppression. In this study at a tertiary liver center in the United States, we evaluated the frequency and virological characteristics of the HBsAg mutations among CHB patients with the presence of both HBsAg and anti-HBs. In this cohort, 45 (2.1%) of 2178 patients were identified to have a coexistence of HBsAg and anti-HBs, and 24 had available sera for the genome analysis of the Pre-S1, Pre-S2, and S regions. The frequency of mutations in the S gene was significantly higher among those older than 50 years (mean 8.5 vs. 5.4 mutations per subject, p = 0.03). Twelve patients (50%) had mutations in the 'alpha' determinant region of the S gene. Mutations at amino acid position 126 were most common in eight subjects. Three had a mutation at position 133. Only one patient had a mutation at position 145-the classic vaccine-escape mutation. Despite the universal HBV vaccination program, the vaccine-escape mutant is rare in our cohort of predominantly Asian patients.
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页数:10
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