Neoadjuvant Treatment of Mismatch Repair-Deficient Colon Cancer - Clinically Meaningful?

被引：3

作者：

Cercek, Andrea ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Div Solid Tumor Oncol, New York, NY 10065 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2024年 / 390卷 / 21期

关键词：

D O I：

10.1056/NEJMe2404601

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of the Journal, Chalabi and colleagues(1) present findings from a large study showing impressive pathological responses of mismatch repair-deficient (dMMR) early-stage colon cancers to neoadjuvant dual immune checkpoint blockade followed by surgical resection. This study was started as a proof-of-principle pilot study with just 1 month of checkpoint blockade therapy followed by standard surgical resection. In the expanded cohort that is described in the current article, approximately two thirds of the patients had a pathological complete response (no residual viable tumor). The authors are to be congratulated on these results, which further highlight the sensitivity of dMMR . . .

引用

页码：2024 / 2025

页数：2

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