The role of mitophagy in the development of chronic kidney disease

被引:8
作者
Yang, Kexin [1 ]
Li, Ting [1 ]
Geng, Yingpu [2 ]
Zou, Xiangyu [1 ]
Peng, Fujun [1 ]
Gao, Wei [1 ]
机构
[1] Shandong Second Med Univ, Sch Basic Med Sci, Dept Pathophysiol, Weifang, Shandong, Peoples R China
[2] Shandong Second Med Univ, Sch Clin Med, Weifang, Shandong, Peoples R China
关键词
Chronic kidney disease; Mitophagy; Renal fibrosis; Mitochondria; REGULATES MITOCHONDRIAL DYNAMICS; PATHOPHYSIOLOGICAL ROLES; BNIP3; HYPOXIA; PROTEIN; MECHANISMS; INDUCTION; AUTOPHAGY; INJURY; NIX;
D O I
10.7717/peerj.17260
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Chronic kidney disease (CKD) represents a significant global health concern, with renal fibrosis emerging as a prevalent and ultimate manifestation of this condition. The absence of targeted therapies presents an ongoing and substantial challenge. Accumulating evidence suggests that the integrity and functionality of mitochondria within renal tubular epithelial cells (RTECs) often become compromised during CKD development, playing a pivotal role in the progression of renal fibrosis. Mitophagy, a specific form of autophagy, assumes responsibility for eliminating damaged mitochondria to uphold mitochondrial equilibrium. Dysregulated mitophagy not only correlates with disrupted mitochondrial dynamics but also contributes to the advancement of renal fibrosis in CKD. While numerous studies have examined mitochondrial metabolism, ROS (reactive oxygen species) production, inflammation, and apoptosis in kidney diseases, the precise pathogenic mechanisms underlying mitophagy in CKD remain elusive. The exact mechanisms through which modulating mitophagy mitigates renal fibrosis, as well as its influence on CKD progression and prognosis, have not undergone systematic investigation. The role of mitophagy in AKI has been relatively clear, but the role of mitophagy in CKD is still rare. This article presents a comprehensive review of the current state of research on regulating mitophagy as a potential treatment for CKD. The objective is to provide fresh perspectives, viable strategies, and practical insights into CKD therapy, thereby contributing to the enhancement of human living conditions and patient well-being.
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页数:26
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