Novel therapies for pediatric acute lymphoblastic leukemia

被引：5

作者：

Graff, Zachary ^{[1
,3
]}

Burke, Michael J. ^{[1
]}

Gossai, Nathan ^{[2
]}

机构：

[1] Med Coll Wisconsin, Div Pediat Hematol Oncol, Milwaukee, WI USA

[2] Childrens Minnesota, Canc & Blood Disorders, Minneapolis, MN USA

[3] MACC Fund Res Ctr, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA

来源：

CURRENT OPINION IN PEDIATRICS | 2024年 / 36卷 / 01期

关键词：

acute lymphoblastic leukemia; childhood leukemia; immunotherapy; targeted therapy; CAR T-CELLS; YOUNG-ADULTS; INOTUZUMAB OZOGAMICIN; STANDARD-RISK; FREE SURVIVAL; B-ALL; CHILDREN; CHEMOTHERAPY; BLINATUMOMAB; INHIBITOR;

D O I：

10.1097/MOP.0000000000001316

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Purpose of reviewThis review summarizes the current novel therapy landscape in pediatric acute lymphoblastic leukemia (ALL), with a focus on key clinical trials which will shape the future direction of care for these children.Recent findingsRecent landmark immunotherapy trials in B-ALL have demonstrated significant benefit for children, adolescents, and young adults with relapsed/refractory high-risk leukemia. Due to these successes, current trials are asking the question as to whether immunotherapy can be successfully incorporated upfront. Additionally, therapies targeting novel antigens or molecular pathways are being developed, providing new options for children previously thought to have incurable leukemia.SummaryAs survival for ALL has relatively plateaued with maximizing intensity through conventional chemotherapy, continued preclinical and clinical study of novel immunotherapeutic and targeted agents is crucial to further improve outcomes in childhood leukemia.

引用

页码：64 / 70

页数：7

共 47 条

[1] Excellent Outcomes With Reduced Frequency of Vincristine and Dexamethasone Pulses in Standard-Risk B-Lymphoblastic Leukemia: Results From Children's Oncology Group AALL0932 [J].

Angiolillo, Anne L. ;

Schore, Reuven J. ;

Kairalla, John A. ;

Devidas, Meenakshi ;

Rabin, Karen R. ;

Zweidler-McKay, Patrick ;

Borowitz, Michael J. ;

Wood, Brent ;

Carroll, Andrew J. ;

Heerema, Nyla A. ;

Relling, Mary V. ;

Hitzler, Johann ;

Lane, Ashley R. ;

Maloney, Kelly W. ;

Wang, Cindy ;

Bassal, Mylene ;

Carroll, William L. ;

Winick, Naomi J. ;

Raetz, Elizabeth A. ;

Loh, Mignon L. ;

Hunger, Stephen P. .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (13) :1437-+

[2] Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia [J].

Bride, Karen L. ;

Vincent, Tiffaney L. ;

Im, Soo-Yeon ;

Aplenc, Richard ;

Barrett, David M. ;

Carroll, William L. ;

Carson, Robin ;

Dai, Yunfeng ;

Devidas, Meenakshi ;

Dunsmore, Kimberly P. ;

Fuller, Tori ;

Glisovic-Aplenc, Tina ;

Horton, Terzah M. ;

Hunger, Stephen P. ;

Loh, Mignon L. ;

Maude, Shannon L. ;

Raetz, Elizabeth A. ;

Winter, Stuart S. ;

Grupp, Stephan A. ;

Hermiston, Michelle L. ;

Wood, Brent L. ;

Teachey, David T. .

BLOOD, 2018, 131 (09) :995-999

[3] Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia A Randomized Clinical Trial [J].

Brown, Patrick A. ;

Ji, Lingyun ;

Xu, Xinxin ;

Devidas, Meenakshi ;

Hogan, Laura E. ;

Borowitz, Michael J. ;

Raetz, Elizabeth A. ;

Zugmaier, Gerhard ;

Sharon, Elad ;

Bernhardt, Melanie B. ;

Terezakis, Stephanie A. ;

Gore, Lia ;

Whitlock, James A. ;

Pulsipher, Michael A. ;

Hunger, Stephen P. ;

Loh, Mignon L. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (09) :833-842

[4]

Brown PA, 2021, LEUKEMIA, V35, P1279, DOI 10.1038/s41375-021-01177-6

[5] Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia [J].

Chiesa, Robert ;

Georgiadis, Christos ;

Syed, Farhatullah ;

Zhan, Hong ;

Etuk, Annie ;

Gkazi, Soragia Athina ;

Preece, Roland ;

Ottaviano, Giorgio ;

Braybrook, Toni ;

Chu, Jan ;

Kubat, Agnieszka ;

Adams, Stuart ;

Thomas, Rebecca ;

Gilmour, Kimberly ;

O'Connor, David ;

Vora, Ajay ;

Qasim, Waseem .

NEW ENGLAND JOURNAL OF MEDICINE, 2023, 389 (10) :899-910

[6] Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199 [J].

Chonghaile, Triona Ni ;

Roderick, Justine E. ;

Glenfield, Cian ;

Ryan, Jeremy ;

Sallan, Stephen E. ;

Silverman, Lewis B. ;

Loh, Mignon L. ;

Hunger, Stephen P. ;

Wood, Brent ;

DeAngelo, Daniel J. ;

Stone, Richard ;

Harris, Marian ;

Gutierrez, Alejandro ;

Kelliher, Michelle A. ;

Letai, Anthony .

CANCER DISCOVERY, 2014, 4 (09) :1074-1087

[7] CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial [J].

Cordoba, Shaun ;

Onuoha, Shimobi ;

Thomas, Simon ;

Pignataro, Daniela Soriano ;

Hough, Rachael ;

Ghorashian, Sara ;

Vora, Ajay ;

Bonney, Denise ;

Veys, Paul ;

Rao, Kanchan ;

Lucchini, Giovanna ;

Chiesa, Robert ;

Chu, Jan ;

Clark, Liz ;

Fung, Mei Mei ;

Smith, Koval ;

Peticone, Carlotta ;

Al-Hajj, Muhammad ;

Baldan, Vania ;

Ferrari, Mathieu ;

Srivastava, Saket ;

Jha, Ram ;

Vargas, Frederick Arce ;

Duffy, Kevin ;

Day, William ;

Virgo, Paul ;

Wheeler, Lucy ;

Hancock, Jeremy ;

Farzaneh, Farzin ;

Domning, Sabine ;

Zhang, Yiyun ;

Khokhar, Nushmia Z. ;

Peddareddigari, Vijay G. R. ;

Wynn, Robert ;

Pule, Martin ;

Amrolia, Persis J. .

NATURE MEDICINE, 2021, 27 (10) :1797-+

[8] Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia [J].

Diaz-Flores, Ernesto ;

Comeaux, Evan Q. ;

Kim, Kailyn L. ;

Melnik, Ella ;

Beckman, Kyle ;

Davis, Kara L. ;

Wu, Kevin ;

Akutagawa, Jon ;

Bridges, Olga ;

Marino, Roberta ;

Wohlfeil, Margo ;

Braun, Benjamin S. ;

Mullighan, Charles G. ;

Loh, Mignon L. .

CANCER RESEARCH, 2019, 79 (09) :2339-2351

[9] Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies [J].

DiJoseph, JF ;

Armellino, DC ;

Boghaert, ER ;

Khandke, K ;

Dougher, MM ;

Sridharan, L ;

Kunz, A ;

Hamann, PR ;

Gorovits, B ;

Udata, C ;

Moran, JK ;

Popplewell, AG ;

Stephens, S ;

Frost, P ;

Damle, NK .

BLOOD, 2004, 103 (05) :1807-1814

[10] Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the philadelphia chromosome. [J].

Druker, BJ ;

Sawyers, CL ;

Kantarjian, H ;

Resta, DJ ;

Reese, SF ;

Ford, JM ;

Capdeville, R ;

Talpaz, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) :1038-1042

← 1 2 3 4 5 →