Hedyotis diffusa Willd inhibits inflammation and oxidative stress to protect against chronic prostatitis via the NRF2/ARE signaling pathway

被引：1
作者：
Mo, Junfu [1 ]
Xia, Kang [1 ]
Wu, Chaokui [1 ]
机构：
[1] Guangzhou Univ Chinese Med, Chongqing Hosp, Affiliated Hosp 1, Dept Urol, 380 Jiangjun Rd, Chongqing 400700, Peoples R China
来源：
ENVIRONMENTAL TOXICOLOGY | 2024年
关键词：
chronic prostatitis/chronic pelvic pain syndrome; Hedyotis diffusa Willd; inflammation; NRF2/ARE pathway; oxidative stress; PELVIC PAIN SYNDROME; NF-KAPPA-B;
D O I：
10.1002/tox.24298
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a common and serious disease with unclear pathogenesis and recurrent symptoms. Hedyotis diffusa Willd (HDW) has been recognized for its potential in managing various chronic inflammatory diseases. This research aimed to interrogate the mechanism of HDW in treating CP/CPPS. Complete Freund Adjuvant (CFA) and LPS were utilized to establish the rat and cell models of CP/CPPS. Results showed that HDW decreased levels of inflammation-related factors in CP rat prostate tissue and LPS-elicited RWPE-1 cell injury model. Moreover, HDW administration impaired oxidative stress in the prostate and RWPE-1 cells. In addition, HDW treatment activated the NRF2/ARE signaling in rat prostate tissue and cell models. Interestingly, NRF2/ARE pathway inhibitor ML385 reversed the inhibition effects of cell apoptosis, inflammation, and oxidative stress triggered by HDW. In summary, HDW alleviated inflammation and oxidative stress by activating NRF2/ARE signaling in CP/CPPS rat model and human prostate epithelial cell injury model.
引用
收藏
页码：4221 / 4230
页数：10
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