Postbiotics in inflammatory bowel disease: efficacy, mechanism, and therapeutic implications

被引：3

作者：

Wang, Shuxin ^{[1
]}

Wang, Pu ^{[1
]}

Wang, Donghui ^{[1
]}

Shen, Shenghai ^{[1
]}

Wang, Shiqi ^{[1
]}

Li, Yuanyuan ^{[2
]}

Chen, Hao ^{[1
]}

机构：

[1] Shandong Univ, Marine Coll, Weihai, Peoples R China

[2] Cornell Univ, Dept Food Sci, Ithaca, NY USA

来源：

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE | 2025年 / 105卷 / 02期

基金：

中国国家自然科学基金;

关键词：

postbiotics; probiotics; inflammatory bowel disease; short-chain fatty acids; bacteriocins; extracellular polysaccharides; CHAIN FATTY-ACIDS; SODIUM-INDUCED COLITIS; GUT MICROBIOTA; BARRIER FUNCTION; ANTIINFLAMMATORY CAPACITY; EXTRACELLULAR VESICLES; INTESTINAL BARRIER; LIPOTEICHOIC ACID; DOUBLE-BLIND; BUTYRATE;

D O I：

10.1002/jsfa.13721

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Inflammatory bowel disease (IBD) is one of the most challenging diseases in the 21st century, and more than 10 million people around the world suffer from IBD. Because of the limitations and adverse effects associated with conventional IBD therapies, there has been increased scientific interest in microbial-derived biomolecules, known as postbiotics. Postbiotics are defined as the preparation of inanimate microorganisms and/or their components that confer a health benefit on the host, comprising inactivated microbial cells, cell fractions, metabolites, etc. Postbiotics have shown potential in enhancing IBD treatment by reducing inflammation, modulating the immune system, stabilizing intestinal flora and maintaining the integrity of intestinal barriers. Consequently, they are considered promising adjunctive therapies for IBD. Recent studies indicate that postbiotics offer distinctive advantages, including spanning clinical (safe origin), technological (easy for storage and transportation) and economic (reduced production costs) dimensions, rendering them suitable for widespread applications in functional food/pharmaceutical. This review offers a comprehensive overview of the definition, classification and applications of postbiotics, with an emphasis on their biological activity in both the prevention and treatment of IBD. (c) 2024 Society of Chemical Industry.

引用

页码：721 / 734

页数：14

共 151 条

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